In phylum Echinodermata, the family Holothuridae is distinguished by its capacity of bioactive compounds. Sea cucumber Holothuria atra is commonly known as the lollyfish. The antifungal activity was detected using aga...In phylum Echinodermata, the family Holothuridae is distinguished by its capacity of bioactive compounds. Sea cucumber Holothuria atra is commonly known as the lollyfish. The antifungal activity was detected using agar well diffusion method against the various fungal strains such as Trichoderma viride, Aspergillus niger, Aspergillus flavis, Candida albicans and Penicillium chrysogenum. Relatively high antifungal activity was seen against Candida albicans at 100 μL-1 concentration of extracts. Zone of inhibition was measured at 18 mm of diameter. The anti-tumor activities were detected against the Vero and Hep2 cell lines using MTT assay. The cells were treated with H. atra extract at concentrations 0.078-10 mg m L-1. The extract showed high proliferative activity against the Hep2 cells. The body wall extracts of sea cucumber(H. atra) showed effective antifungal and antitumor activities. All these findings suggest that the extracts could be used for the development of drugs.展开更多
Objective:To study the pharmacological properties of Sigmadocia pumila(S.pumila),a marine sponge,through in-vivo analysis.Methods:The anti-inflammatory activity was determined by the carrageenan-induced rat paw edema ...Objective:To study the pharmacological properties of Sigmadocia pumila(S.pumila),a marine sponge,through in-vivo analysis.Methods:The anti-inflammatory activity was determined by the carrageenan-induced rat paw edema method.The analgesic activity was analyzed by tail immersion method.Antipyretic activity was done by using Brewer’s yeast induced hyperpyrexia method.Results:The anti-inflammatory activity using methanol extracts in S.pumila at the concentrations of 100 mg/kg and 200 mg/kg,(p.o.)on rats showed significant decrease in the paw thickness at the 5th h of administration.It was denoted that the S.pumila exerted more analgesic activity.As for the antipyretic activity during the 2nd and 3rd h,the 3rd and 4th group of rats showed the reduction in temperature in S.pumila at 100 mg/kg and 200 mg/kg dosages.Conclusions:The present study concludes that the marine sponge S.pumila acts as a vital role in exhibiting pharmaceutical activities.It could be used to produce novel drugs.展开更多
文摘In phylum Echinodermata, the family Holothuridae is distinguished by its capacity of bioactive compounds. Sea cucumber Holothuria atra is commonly known as the lollyfish. The antifungal activity was detected using agar well diffusion method against the various fungal strains such as Trichoderma viride, Aspergillus niger, Aspergillus flavis, Candida albicans and Penicillium chrysogenum. Relatively high antifungal activity was seen against Candida albicans at 100 μL-1 concentration of extracts. Zone of inhibition was measured at 18 mm of diameter. The anti-tumor activities were detected against the Vero and Hep2 cell lines using MTT assay. The cells were treated with H. atra extract at concentrations 0.078-10 mg m L-1. The extract showed high proliferative activity against the Hep2 cells. The body wall extracts of sea cucumber(H. atra) showed effective antifungal and antitumor activities. All these findings suggest that the extracts could be used for the development of drugs.
文摘Objective:To study the pharmacological properties of Sigmadocia pumila(S.pumila),a marine sponge,through in-vivo analysis.Methods:The anti-inflammatory activity was determined by the carrageenan-induced rat paw edema method.The analgesic activity was analyzed by tail immersion method.Antipyretic activity was done by using Brewer’s yeast induced hyperpyrexia method.Results:The anti-inflammatory activity using methanol extracts in S.pumila at the concentrations of 100 mg/kg and 200 mg/kg,(p.o.)on rats showed significant decrease in the paw thickness at the 5th h of administration.It was denoted that the S.pumila exerted more analgesic activity.As for the antipyretic activity during the 2nd and 3rd h,the 3rd and 4th group of rats showed the reduction in temperature in S.pumila at 100 mg/kg and 200 mg/kg dosages.Conclusions:The present study concludes that the marine sponge S.pumila acts as a vital role in exhibiting pharmaceutical activities.It could be used to produce novel drugs.
