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Unveiling ferroptosis as a promising therapeutic avenue for colorectal cancer and colitis treatment
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作者 aaron t.kaoy Christian V.Cabanlongy +1 位作者 Kendra Padilla Xiang Xue 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2024年第9期3785-3801,共17页
Ferroptosis is a novel type of regulated cell death(RCD)involving iron accumulation and lipid peroxidation.Since its discovery in 2012,various studies have shown that ferroptosis is associated with the pathogenesis of... Ferroptosis is a novel type of regulated cell death(RCD)involving iron accumulation and lipid peroxidation.Since its discovery in 2012,various studies have shown that ferroptosis is associated with the pathogenesis of various diseases.Ferroptotic cell death has also been linked to intestinal dysfunction but can act as either a positive or negative regulator of intestinal disease,depending on the cell type and disease context.The continued investigation of mechanisms underlying ferroptosis provides a wealth of potential for developing novel treatments.Considering the growing prevalence of intestinal diseases,particularly colorectal cancer(CRC)and inflammatory bowel disease(IBD),this review article focuses on potential therapeutics targeting the ferroptotic pathway in relation to CRC and IBD. 展开更多
关键词 Ferroptosis Colorectal cancer Inflammatory bowel disease Cell death Molecular mechanisms Iron metabolism Drug therapies Targeted therapeutics
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