Context: Evidence suggests that physical activity may be related to the clinic al expression of dementia. Whether the association includes low intensity activ ity such as walking is not known. Objective: To examine th...Context: Evidence suggests that physical activity may be related to the clinic al expression of dementia. Whether the association includes low intensity activ ity such as walking is not known. Objective: To examine the association between walking and future risk of dementia in older men. Design: Prospective cohort stu dy. Setting and Participants: Distance walked per day was assessed from 1991 to 1993 in 2257 physically capable men aged 71 to 93 years in the Honolulu Asia Ag ing Study. Fol low up for incident dementia was based on neurological assessme nt at 2 repeat examinations (1994-1996 and 1997-1999). Main Outcome Measures: Overall dementia, Alzheimer disease, and vascular dementia. Results: During the course of follow up, 158 cases of dementia were identified (15.6/1000 person y ears). After adjusting for age, men who walked the least ( < 0.25 mile/d) experi enced a 1.8 fold excess risk of dementia compared with those who walked more th an 2 mile/d (17.8 vs 10.3/1000 person years; relative hazard [RH], 1.77; 95% co nfidenceinterval [CI], 1.04-3.01). Compared with men who walked the most ( > 2 mile/d), an excess risk of dementia was alsoobserved in those who walked 0.25 to 1 mile/d (17.6 vs 10.3/1000 person years; RH, 1.71; 95%CI, 1.02-2.86). These associations persisted after accounting for other factors, including the possib ility that limited amounts of walking could be the result of a decline in physic al function due to preclinical dementia. Conclusions: Findings suggest that walk ing is associated with a reduced risk of dementia. Promoting active lifestyles i n physically capable men could help late life cognitive function.展开更多
文摘Context: Evidence suggests that physical activity may be related to the clinic al expression of dementia. Whether the association includes low intensity activ ity such as walking is not known. Objective: To examine the association between walking and future risk of dementia in older men. Design: Prospective cohort stu dy. Setting and Participants: Distance walked per day was assessed from 1991 to 1993 in 2257 physically capable men aged 71 to 93 years in the Honolulu Asia Ag ing Study. Fol low up for incident dementia was based on neurological assessme nt at 2 repeat examinations (1994-1996 and 1997-1999). Main Outcome Measures: Overall dementia, Alzheimer disease, and vascular dementia. Results: During the course of follow up, 158 cases of dementia were identified (15.6/1000 person y ears). After adjusting for age, men who walked the least ( < 0.25 mile/d) experi enced a 1.8 fold excess risk of dementia compared with those who walked more th an 2 mile/d (17.8 vs 10.3/1000 person years; relative hazard [RH], 1.77; 95% co nfidenceinterval [CI], 1.04-3.01). Compared with men who walked the most ( > 2 mile/d), an excess risk of dementia was alsoobserved in those who walked 0.25 to 1 mile/d (17.6 vs 10.3/1000 person years; RH, 1.71; 95%CI, 1.02-2.86). These associations persisted after accounting for other factors, including the possib ility that limited amounts of walking could be the result of a decline in physic al function due to preclinical dementia. Conclusions: Findings suggest that walk ing is associated with a reduced risk of dementia. Promoting active lifestyles i n physically capable men could help late life cognitive function.
