Background: Colchicine intoxication is uncommon but potentially life threatening because of the high toxicity of the drug. Colchicine binds to the intracellular protein tubulin, causing disturbed mitosis in all tissue...Background: Colchicine intoxication is uncommon but potentially life threatening because of the high toxicity of the drug. Colchicine binds to the intracellular protein tubulin, causing disturbed mitosis in all tissues followed by multi-organ failure. Case Presentation: We report a case of a 23-year-old woman admitted to emergency room 12 hours after a suicide attempt by ingestion of approximatively 40 mg of colchicine. Few hours after consumption, first symptoms were a hemodynamic shock and ARDS, leading to her death due to multi-organ failure. Conclusion: The colchicine intoxication has strong morbidity for doses higher than 0.5 mg/kg. The treatment is symptomatic. The immunotherapy using anti-colchicine allows improving critical form’s prognosis.展开更多
Background: Pneumomediastinum and subcutaneous emphysema are a rare and well-known complication of dental procedures. Many cases go unrecognized and resolve spontaneously, while others may require specific therapeutic...Background: Pneumomediastinum and subcutaneous emphysema are a rare and well-known complication of dental procedures. Many cases go unrecognized and resolve spontaneously, while others may require specific therapeutic management to prevent complications. Case Presentations: We report a case of cervical subcutaneous emphysema and pneumomediasitnum occurring after extraction of lower right second molar. The emphysema was detected 2 hours after dental surgery. This paper reports on the diagnosis and treatment of subcutaneous emphysema and pneumomediastinum. Conclusion: In order to prevent this complication, air turbine high speed drills should be used only in necessary cases.展开更多
文摘Background: Colchicine intoxication is uncommon but potentially life threatening because of the high toxicity of the drug. Colchicine binds to the intracellular protein tubulin, causing disturbed mitosis in all tissues followed by multi-organ failure. Case Presentation: We report a case of a 23-year-old woman admitted to emergency room 12 hours after a suicide attempt by ingestion of approximatively 40 mg of colchicine. Few hours after consumption, first symptoms were a hemodynamic shock and ARDS, leading to her death due to multi-organ failure. Conclusion: The colchicine intoxication has strong morbidity for doses higher than 0.5 mg/kg. The treatment is symptomatic. The immunotherapy using anti-colchicine allows improving critical form’s prognosis.
文摘Background: Pneumomediastinum and subcutaneous emphysema are a rare and well-known complication of dental procedures. Many cases go unrecognized and resolve spontaneously, while others may require specific therapeutic management to prevent complications. Case Presentations: We report a case of cervical subcutaneous emphysema and pneumomediasitnum occurring after extraction of lower right second molar. The emphysema was detected 2 hours after dental surgery. This paper reports on the diagnosis and treatment of subcutaneous emphysema and pneumomediastinum. Conclusion: In order to prevent this complication, air turbine high speed drills should be used only in necessary cases.
