Association between the Presence of Serumanti-Cardiolipin Antibodies and Infertility

Background: Infertility is a common problem affecting 15% - 20% of couples. The increased incidence of anticardiolipin (ACL) antibodies in infertile women supports the contention that these autoantibodies contribute to the infertility. Objectives: To investigate whether there is an association between the presence of serum ACL antibodies and infertility in both men and women in Diyala province. Subjects and methods: The present study was conducted in Baquba city for the period from October 2013 to November 2014. Subjects included in this study were chosen from those attending Baquba Teaching Hospital, Al-Batool Teaching Hospital for Maternity and Children and some Primary Health Care Centers in Baquba. The subjects were categorized as follows: 30 apparently healthy males with age ranged between (18 - 45) years;30 apparently healthy women (age range: 18 - 47 years) had at least two live births without any miscarriages;25 women (age range: 18 - 43 years) had reproductive failure for at least one year of marriage;30 women (age range: 24 - 44 years) with at least one live birth had no pregnancy for at least two years after last child;40 males with primary infertility (no children after at least five years of marriage and their active sperm count was zero). Detection of anti-ACL IgG and IgM was done using enzyme-linked immunosorbant assay (ELISA) commercial kits (Wendell/Shelm/Germany). All data were statistically analyzed. Results: The results revealed that the anti-ACL IgM positivity rate was significantly higher among women with primary fertility compared to healthy women (p = 0.006). Similarly, the anti-ACL IgM and anti-ACL IgG were significantly among women with secondary infertility compared to healthy women (p = 0.012) and (p = 0.038) respectively. Although the anti-ACL IgG and IgM positivity rate among men with primary infertility was higher than that of healthy control. However, the differences were failed to reach the statistical significance (p = 0.07) and (p = 0.31) respectively. Conclusion: The presence of high levels of anticardiolipin antibodies in women with primary and secondary infertility as well as in men with primary infertility may support the contention that these autoantibodies contribute to the infertility in both sexes.

Erratum to “Association between the Presence of Serumanti-Cardiolipin Antibodies and Infertility” [Journal of Biosciences and Medicines 4 (2016) 95-100]

The original online version of this article (Hasan, A.-R.Sh., Hwaid, A.H. and Mahdy, Z.H. (2016) Association between the Presence of Serumanti-Cardiolipin Antibodies and Infertility. Journal of Biosciences and Medicines, 4, 95-100. http://dx.doi.org/10.4236/jbm.2016.41011) was published as a mistake in the names of researchers in authorship paper. To reflect the contribution and responsibility of the first author as well as the affiliations of the authors at the time of the study, we have revised the authorship and author affiliations of this article. The author wishes to correct the errors as: Rafah Oday Hussien1, Abdul-Razak Sh. Hasan2 1Department of Health Community, Technical Institute, Baqubah, Diyala, Iraq 2Department of Microbiology, College of Medicine, Diyala University, Diyala,