Magnesium-reinforced Electrospun Synthetic-polymer Nanofibers Designed for Promoting Tissue Growth

The creation of 3D nanofibers offering desirable functions for bone regeneration is developed due to the latest improvisations to the electrospinning technique.Synthetic polymers are among the best choices for medical usage due to their lower costs,high tensile properties,and ease of spinnability compared to natural polymers.In this communication,we report a series of interventions to polymers modified with Mg-based fillers for ideal tissue engineering applications.The literature survey indicated that these filler materials(e.g.,nano-sized particles)enhanced biocompatibility,antibacterial activity,tensile strength,and anti-corrosive properties.This review discusses electrospinning parameters,properties,and applications of the poly(ε-caprolactone),poly(lactic acid),poly(3-hydroxybutyric acid-co-3-hydroxy valeric acid),polyurethane,and poly(vinyl pyrrolidone)nanofibers when modified with Mg-based fillers.This report encourages researchers to use synthetic polymers with Mg as fillers and validate them for tissue engineering applications.

Recent progress in MXenes incorporated into electrospun nanofibers for biomedical application: Study focusing from 2017 to 2022

After discovering a new class of two-dimensional(2D) material, i.e., MXene, a further new scope, came into existence for researchers. Due to their remarkable physical, chemical, and biological properties, MXenes find their role in almost every research discipline. They have been used in biosensors, bioimaging,tissue engineering, drug delivery systems, and other areas. The MXenes can be functionalized with a wide range of atoms/molecules, making them diverse materials. Therefore, the potential of using MXenes in nanofibers can be much more than expected. In this review, we will understand the structure, synthesis,and general properties of MXenes. We will explain using MXenes while encasing them into nanofibers,providing their specific properties. For instance, MXenes-incorporated nanofibers are used in biomedical applications, including soft and hard-tissue engineering and delivery of antimicrobials. Furthermore, MXenes, when incorporated into nanofibers, are used in promoting cellular differentiation, wound healing,and neural tissue restoration, which are briefly discussed in this communication.