To evaluate the contribution of hematologic factors and longterm inflammation to the development of myocardial infarction at a young age, we measured hematolo gic variables, including soluble fibrin and high-sensitivi...To evaluate the contribution of hematologic factors and longterm inflammation to the development of myocardial infarction at a young age, we measured hematolo gic variables, including soluble fibrin and high-sensitivity C-reactive protei n, in 90 patients who had myocardial infarction and 138 controls ≤45 years of a ge. Plasma levels of soluble fibrin and C-reactive protein were significantly h igher in patients than in controls. On multivariate regression analysis, soluble fibrin was the strongest predictor of myocardial infarction at a young age.展开更多
PURPOSE: This study was designed to look for significant correlations between location of early colorectal cancer, distance from muscularis mucosae to muscularis propria, and the frequency of lymph node metastasis. ME...PURPOSE: This study was designed to look for significant correlations between location of early colorectal cancer, distance from muscularis mucosae to muscularis propria, and the frequency of lymph node metastasis. METHODS: A total of 166 early colorectal cancers, including 67 surgically resected lesions, were evaluated. The cancers were divided into two groups: metastatic and nonmetastatic. Cancer lesions were further subtyped at the fold-top or fold-bottom. Macroscopic classifications and histology were performed. Absolute invasive depth and distance from muscularis mucosae to muscularis propria was measured. Multivariate analysis was used to assess relationships among the variables. RESULTS: The percentage of polypoid cancer lesions at fold-bottom was higher than at fold-top (74.5 vs. 51.8 percent), whereas flat-type cancer lesions at fold-bottom occurred less often than at fold-top (8.2 vs. 30.4 percent). Logistic regression showed that deep absolute invasive depth, lymphatic and vessel invasion,and cancer location (at fold-bottom) were the significant risk factors for early colorectal cancers leading to lymph-node metastasis. The distance from muscularis mucosae to muscularis propria with lymph node metastasis (1,396.7 ±728.4 μm) was shorter than without lymph node metastasis (3,533.9 ±2,507.8 μm; P < 0.01). Multivariate analysis showed that distance from muscularis mucosae to muscularis propria was a statistically significant factor for early colorectal cancers leading to lymph node metastasis (P = 0.0054). CONCLUSIONS:We conclude that early colorectal cancers at the fold-top or with a long distance from muscularis mucosae to muscularis propria have less tendency to metastasize to lymph nodes. Clinically, these results provide evidence of a new indicator of endoscopic mucosal resection for early colorectal cancers at the fold-top.展开更多
Background/Aims Diabetes mellitus (DM) is frequently observed in patients with chronic hepatitis caused by hepatitis C virus infection (CHC). The present study was designed to determine the pathogenic factors responsi...Background/Aims Diabetes mellitus (DM) is frequently observed in patients with chronic hepatitis caused by hepatitis C virus infection (CHC). The present study was designed to determine the pathogenic factors responsible for glucose intolerance in CHC patients. Methods A total of 131 patients with CHC were enrolled in this study. Insulin resistance and β-cell function were determined after 75 g oral glucose tolerance tests. Results Glucose intolerance was detected in 27.5% (36/131) of CHC patients; 10 had DM and 26 impaired glucose tolerance. HOMA-R insulin 0× glucose 0/22.5 was greater in patients with both impaired glucose tolerance and DM than in those with normal glucose tolerance (P< 0.01). Matsuda index 104/√ (mean insulin× mean glucose× glucose0× insulin 0) was lower in diabetic patients than in those with normal glucose tolerance (P< 0.05). The insulinogenic indexΔ insulin 30-0/Δ glucose 30-0 and Δ C-peptide 30 Δ C-peptide30-0/Δ glucose 30-0 were significantly lower even in patients with impaired glucose tolerance than in patients with normal glucose tolerance (P< 0.01). Conclusions Both insulin resistance and β-cell dysfunction contribute to glucose intolerance in CHC patients.展开更多
文摘To evaluate the contribution of hematologic factors and longterm inflammation to the development of myocardial infarction at a young age, we measured hematolo gic variables, including soluble fibrin and high-sensitivity C-reactive protei n, in 90 patients who had myocardial infarction and 138 controls ≤45 years of a ge. Plasma levels of soluble fibrin and C-reactive protein were significantly h igher in patients than in controls. On multivariate regression analysis, soluble fibrin was the strongest predictor of myocardial infarction at a young age.
文摘PURPOSE: This study was designed to look for significant correlations between location of early colorectal cancer, distance from muscularis mucosae to muscularis propria, and the frequency of lymph node metastasis. METHODS: A total of 166 early colorectal cancers, including 67 surgically resected lesions, were evaluated. The cancers were divided into two groups: metastatic and nonmetastatic. Cancer lesions were further subtyped at the fold-top or fold-bottom. Macroscopic classifications and histology were performed. Absolute invasive depth and distance from muscularis mucosae to muscularis propria was measured. Multivariate analysis was used to assess relationships among the variables. RESULTS: The percentage of polypoid cancer lesions at fold-bottom was higher than at fold-top (74.5 vs. 51.8 percent), whereas flat-type cancer lesions at fold-bottom occurred less often than at fold-top (8.2 vs. 30.4 percent). Logistic regression showed that deep absolute invasive depth, lymphatic and vessel invasion,and cancer location (at fold-bottom) were the significant risk factors for early colorectal cancers leading to lymph-node metastasis. The distance from muscularis mucosae to muscularis propria with lymph node metastasis (1,396.7 ±728.4 μm) was shorter than without lymph node metastasis (3,533.9 ±2,507.8 μm; P < 0.01). Multivariate analysis showed that distance from muscularis mucosae to muscularis propria was a statistically significant factor for early colorectal cancers leading to lymph node metastasis (P = 0.0054). CONCLUSIONS:We conclude that early colorectal cancers at the fold-top or with a long distance from muscularis mucosae to muscularis propria have less tendency to metastasize to lymph nodes. Clinically, these results provide evidence of a new indicator of endoscopic mucosal resection for early colorectal cancers at the fold-top.
文摘Background/Aims Diabetes mellitus (DM) is frequently observed in patients with chronic hepatitis caused by hepatitis C virus infection (CHC). The present study was designed to determine the pathogenic factors responsible for glucose intolerance in CHC patients. Methods A total of 131 patients with CHC were enrolled in this study. Insulin resistance and β-cell function were determined after 75 g oral glucose tolerance tests. Results Glucose intolerance was detected in 27.5% (36/131) of CHC patients; 10 had DM and 26 impaired glucose tolerance. HOMA-R insulin 0× glucose 0/22.5 was greater in patients with both impaired glucose tolerance and DM than in those with normal glucose tolerance (P< 0.01). Matsuda index 104/√ (mean insulin× mean glucose× glucose0× insulin 0) was lower in diabetic patients than in those with normal glucose tolerance (P< 0.05). The insulinogenic indexΔ insulin 30-0/Δ glucose 30-0 and Δ C-peptide 30 Δ C-peptide30-0/Δ glucose 30-0 were significantly lower even in patients with impaired glucose tolerance than in patients with normal glucose tolerance (P< 0.01). Conclusions Both insulin resistance and β-cell dysfunction contribute to glucose intolerance in CHC patients.
