Introduction: Pyogenic spondylodiscitis is a rare and severe complication of laparoscopic Sacro-Hysteropexy with a polypropylene mesh. The proper and early diagnosis following by medical treatment, if not responding, ...Introduction: Pyogenic spondylodiscitis is a rare and severe complication of laparoscopic Sacro-Hysteropexy with a polypropylene mesh. The proper and early diagnosis following by medical treatment, if not responding, so we shift to surgical approach is very important to prevent irreversible complications. Case Presentation: A female patient 32 years old admitted to our Gyne-Oncology unit in El-Galaa Maternity Teaching Hospital, in Jan 2022 with a significant weakness in both lower limbs up to complete paralysis, by history she has done a laparoscopic Hystero-Sacro-Pexy with synthetic polypropylene mesh 2 weeks ago, all investigations were normal except WBCs was 14,000 and CRP was 28, MRI Finding was an Encysted collection likely seroma at sacral promontory 4 × 3 cm, surgical removal of the mesh was done, the mesh related to the sacrum was severely infected and pus formation was noticed, 4 hours after the operation there was a Dramatic response and complete resolution of symptoms within few days. Conclusion: Because of the rarity of this complication in the literature, Spondylodiscitis awareness of symptoms, timely diagnosis, and treatment including surgical removal of synthetic mesh after Sacro-Pexy are fundamental to prevent irreversible complications.展开更多
Objectives: Serous ovarian carcinoma (SOC) is the commonest ovarian carcinoma type with poor prognosis due to early metastasis and first presentation with advanced stage. In this work, we investigated serum level of G...Objectives: Serous ovarian carcinoma (SOC) is the commonest ovarian carcinoma type with poor prognosis due to early metastasis and first presentation with advanced stage. In this work, we investigated serum level of Galactin-1 (Gal-1) and its tissue immunohistochemical expression in SOC patients at different stages trying to find out its significance as a diagnostic and prognostic marker. Patients and methods: The study included 95 females I-Control group: Twenty five healthy females;II-Patients group: Seventy females diagnosed as SOC at different stages;Stage I: 8 cases, Stage II: 12 cases, Stage III: 32 cases and Stage VI:18 cases. Serum Galectin-1 and CA-125 were measured by ELIZA and tissue Galectin-1 was assessed by immunohistochemistry. All patients were followed for up to 3 years after surgery. Results: Serum Gal-1 and CA-125 levels were significantly higehr in SOC patients compared to controls (p 0.001). We found a direct positive statistically significant correlation between serum Gal-1 and CA125 levels (p 0.001). Serum Gal-1 at cut off value > 135 ng/ml was superior to CA-125 a cut off value > 49 u/ml with sensitivity, specificity of 100%, vs 88.57, 96% for CA-125. Serum Gal-1 was significantly associated with tumor stage (p 0.001). Immunohistochemistry showed that patients with strong Gal-1 expression had higher serum level (p = 0.002). Stromal and tumor Gal-1 expression were significantly correlated with tumor grade (p 0.001) and stage (p = 0.001). Serum Gal-1, CA-125 and IHC Gal-1 expression were associated with poor survival (p 0.001, p = 0.009 and p = 0.002) respectively. Conclusion: Serum Gal-1 and its tissue IHC expression are useful diagnostic and prognostic markers for SOC patients.展开更多
文摘Introduction: Pyogenic spondylodiscitis is a rare and severe complication of laparoscopic Sacro-Hysteropexy with a polypropylene mesh. The proper and early diagnosis following by medical treatment, if not responding, so we shift to surgical approach is very important to prevent irreversible complications. Case Presentation: A female patient 32 years old admitted to our Gyne-Oncology unit in El-Galaa Maternity Teaching Hospital, in Jan 2022 with a significant weakness in both lower limbs up to complete paralysis, by history she has done a laparoscopic Hystero-Sacro-Pexy with synthetic polypropylene mesh 2 weeks ago, all investigations were normal except WBCs was 14,000 and CRP was 28, MRI Finding was an Encysted collection likely seroma at sacral promontory 4 × 3 cm, surgical removal of the mesh was done, the mesh related to the sacrum was severely infected and pus formation was noticed, 4 hours after the operation there was a Dramatic response and complete resolution of symptoms within few days. Conclusion: Because of the rarity of this complication in the literature, Spondylodiscitis awareness of symptoms, timely diagnosis, and treatment including surgical removal of synthetic mesh after Sacro-Pexy are fundamental to prevent irreversible complications.
文摘Objectives: Serous ovarian carcinoma (SOC) is the commonest ovarian carcinoma type with poor prognosis due to early metastasis and first presentation with advanced stage. In this work, we investigated serum level of Galactin-1 (Gal-1) and its tissue immunohistochemical expression in SOC patients at different stages trying to find out its significance as a diagnostic and prognostic marker. Patients and methods: The study included 95 females I-Control group: Twenty five healthy females;II-Patients group: Seventy females diagnosed as SOC at different stages;Stage I: 8 cases, Stage II: 12 cases, Stage III: 32 cases and Stage VI:18 cases. Serum Galectin-1 and CA-125 were measured by ELIZA and tissue Galectin-1 was assessed by immunohistochemistry. All patients were followed for up to 3 years after surgery. Results: Serum Gal-1 and CA-125 levels were significantly higehr in SOC patients compared to controls (p 0.001). We found a direct positive statistically significant correlation between serum Gal-1 and CA125 levels (p 0.001). Serum Gal-1 at cut off value > 135 ng/ml was superior to CA-125 a cut off value > 49 u/ml with sensitivity, specificity of 100%, vs 88.57, 96% for CA-125. Serum Gal-1 was significantly associated with tumor stage (p 0.001). Immunohistochemistry showed that patients with strong Gal-1 expression had higher serum level (p = 0.002). Stromal and tumor Gal-1 expression were significantly correlated with tumor grade (p 0.001) and stage (p = 0.001). Serum Gal-1, CA-125 and IHC Gal-1 expression were associated with poor survival (p 0.001, p = 0.009 and p = 0.002) respectively. Conclusion: Serum Gal-1 and its tissue IHC expression are useful diagnostic and prognostic markers for SOC patients.