Metal(II) coordination compounds of glycine and ph-enylalanine were synthesized and characterized using infrared and electronic spectroscopic, and magnetic susceptibility measurements. The complexes were tested for an...Metal(II) coordination compounds of glycine and ph-enylalanine were synthesized and characterized using infrared and electronic spectroscopic, and magnetic susceptibility measurements. The complexes were tested for antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Methicillin Resistant Staphy-lococcus aureus (MRSA), Escherichia coli, Pseudo-monas aeruginosa, Proteus vulgaris and Candida albicans. The stoichiometric reaction between the metal (II) ions and ligands in molar ratio M:L (1:3) [where M = Mn, Co, Ni, Cu and Cd;L= glycine;phenylalanine] resulted in the formation of five-coordinate square pyramidal dinuclear geometry for both copper complexes and six-coordinate octa-hedral geometry for the other complexes. The spectroscopic and magnetic moment data suggested that the ligands coordinated via both their amino and carboxylate ion moieties. The complexes demonstrated better activities against one or more of the tested microbes than acriflavine, the standard drug used.展开更多
Extracts and constituents of medicinal plants have proven to be biodegradable, had low mammalian toxicity and induction of resistance, and comparable activities to the standard drugs. Therefore, methanolic extracts of...Extracts and constituents of medicinal plants have proven to be biodegradable, had low mammalian toxicity and induction of resistance, and comparable activities to the standard drugs. Therefore, methanolic extracts of some plants that are termite resistant or used ethnomedically as antimalarial and febrifuge were evaluated for activities against 4th-instar larvae of Aedes aegypti. A 61 % of these plants with these properties demonstrated larvicidal activities and may confirm the usefulness of these properties in choosing plant larvicides. This is the first report of larvicidal activities of stem barks and leaves of Blighia sapida and Baphia nitida, stem barks of Markhamia tomentosa and Newboldia laevis, and whole plants of Euphorbia macrophylla. Extracts of B. sapida stem bark, Costus specious root and Xylopia aethiopica seed, with LC50 1.71, 1.47 and 1.49 mg/ml at 48 h, respectively, were the most active and had significant activities that were comparable to Endosulphan. Hence, they may be used as plant larvicides in the control of dengue and yellow fever.展开更多
文摘Metal(II) coordination compounds of glycine and ph-enylalanine were synthesized and characterized using infrared and electronic spectroscopic, and magnetic susceptibility measurements. The complexes were tested for antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Methicillin Resistant Staphy-lococcus aureus (MRSA), Escherichia coli, Pseudo-monas aeruginosa, Proteus vulgaris and Candida albicans. The stoichiometric reaction between the metal (II) ions and ligands in molar ratio M:L (1:3) [where M = Mn, Co, Ni, Cu and Cd;L= glycine;phenylalanine] resulted in the formation of five-coordinate square pyramidal dinuclear geometry for both copper complexes and six-coordinate octa-hedral geometry for the other complexes. The spectroscopic and magnetic moment data suggested that the ligands coordinated via both their amino and carboxylate ion moieties. The complexes demonstrated better activities against one or more of the tested microbes than acriflavine, the standard drug used.
文摘Extracts and constituents of medicinal plants have proven to be biodegradable, had low mammalian toxicity and induction of resistance, and comparable activities to the standard drugs. Therefore, methanolic extracts of some plants that are termite resistant or used ethnomedically as antimalarial and febrifuge were evaluated for activities against 4th-instar larvae of Aedes aegypti. A 61 % of these plants with these properties demonstrated larvicidal activities and may confirm the usefulness of these properties in choosing plant larvicides. This is the first report of larvicidal activities of stem barks and leaves of Blighia sapida and Baphia nitida, stem barks of Markhamia tomentosa and Newboldia laevis, and whole plants of Euphorbia macrophylla. Extracts of B. sapida stem bark, Costus specious root and Xylopia aethiopica seed, with LC50 1.71, 1.47 and 1.49 mg/ml at 48 h, respectively, were the most active and had significant activities that were comparable to Endosulphan. Hence, they may be used as plant larvicides in the control of dengue and yellow fever.
