Hepcidin is a peptide hormone with both paracrine and endocrine functions that help in maintaining body iron stores.Type 2 diabetes(T2D) is one of the sequelae of excess body iron stores; thus,iron regulatory hormone ...Hepcidin is a peptide hormone with both paracrine and endocrine functions that help in maintaining body iron stores.Type 2 diabetes(T2D) is one of the sequelae of excess body iron stores; thus,iron regulatory hormone hepcidin may have a direct or at least an indirect role in the aetiopathogenesis of T2 D.Both human and animal studies at molecular and genetic levels have attemptedto establish a role for hepcidin in the development of T2 D,and a few epidemiologic studies have also showed a link between hepcidin and T2 D at population level,but the findings are still inconclusive.Recent data have suggested different pathways in which hepcidin could be associated with T2 D with much emphasis on its primary or secondary role in insulin resistance.Some of the suggested pathways are via transcription modulator of hepcidin(STAT3); ferroportin 1 expression on the cells involved in iron transport; transmembrane protease 6 enzyme; and pro-inflammatory cytokines,interleukin(IL)-1,IL-6,tumor necrosis factor-α and IL-10.This review briefly reports the existing evidence on the possible links between hepcidin and T2 D and concludes that more data are needed to confirm or refute hepcidin's role in the development of T2 D.Examining this role could provide a further evidence base for iron in the aetiopathogenesis of T2 D.展开更多
文摘Hepcidin is a peptide hormone with both paracrine and endocrine functions that help in maintaining body iron stores.Type 2 diabetes(T2D) is one of the sequelae of excess body iron stores; thus,iron regulatory hormone hepcidin may have a direct or at least an indirect role in the aetiopathogenesis of T2 D.Both human and animal studies at molecular and genetic levels have attemptedto establish a role for hepcidin in the development of T2 D,and a few epidemiologic studies have also showed a link between hepcidin and T2 D at population level,but the findings are still inconclusive.Recent data have suggested different pathways in which hepcidin could be associated with T2 D with much emphasis on its primary or secondary role in insulin resistance.Some of the suggested pathways are via transcription modulator of hepcidin(STAT3); ferroportin 1 expression on the cells involved in iron transport; transmembrane protease 6 enzyme; and pro-inflammatory cytokines,interleukin(IL)-1,IL-6,tumor necrosis factor-α and IL-10.This review briefly reports the existing evidence on the possible links between hepcidin and T2 D and concludes that more data are needed to confirm or refute hepcidin's role in the development of T2 D.Examining this role could provide a further evidence base for iron in the aetiopathogenesis of T2 D.
