Purpose： Metalloproteinases are a key component of the pathogenesis of abdominal hernias. Obesity is considered a risk factor in herniogenesis and hernia recurrence. The aim of this study was to evaluate the serum co...Purpose： Metalloproteinases are a key component of the pathogenesis of abdominal hernias. Obesity is considered a risk factor in herniogenesis and hernia recurrence. The aim of this study was to evaluate the serum concentrations of metalloproteinase-2（MMP-2）, MMP-9, MMP-13, and adiponectin in morbidly obese and nonoverweight controls. Materials and methods： The participants were recruited from among patients undergoing bariatric and non-bariatric surgery and divided into two groups： I（body mass index（BMI）≥35 kg/m^2, n=40） and II（BMI〈25 kg/m^2, n=30）. Serum concentrations of MMP-2, MMP-9, MMP-13, and adiponectin were measured using enzyme-linked immunosorbent assay（ELISA）. Results： A statistically significant difference between groups was observed for MMP-2 concentration. The median MMP-9 concentration was higher in the obese group, but the difference was not statistically significant. Median MMP-13 concentrations did not differ between groups. Serum adiponectin concentration was insignificantly higher in the non-obese group. Conclusions： The elevated serum MMP-2 and MMP-9 concentrations in obese individuals may be related to the higher incidence of incisional hernias in this population.展开更多
文摘Purpose： Metalloproteinases are a key component of the pathogenesis of abdominal hernias. Obesity is considered a risk factor in herniogenesis and hernia recurrence. The aim of this study was to evaluate the serum concentrations of metalloproteinase-2（MMP-2）, MMP-9, MMP-13, and adiponectin in morbidly obese and nonoverweight controls. Materials and methods： The participants were recruited from among patients undergoing bariatric and non-bariatric surgery and divided into two groups： I（body mass index（BMI）≥35 kg/m^2, n=40） and II（BMI〈25 kg/m^2, n=30）. Serum concentrations of MMP-2, MMP-9, MMP-13, and adiponectin were measured using enzyme-linked immunosorbent assay（ELISA）. Results： A statistically significant difference between groups was observed for MMP-2 concentration. The median MMP-9 concentration was higher in the obese group, but the difference was not statistically significant. Median MMP-13 concentrations did not differ between groups. Serum adiponectin concentration was insignificantly higher in the non-obese group. Conclusions： The elevated serum MMP-2 and MMP-9 concentrations in obese individuals may be related to the higher incidence of incisional hernias in this population.
