Objective: To assess whether pregnancy rate differs in unilateral vs bilateral transfer in “immediate transfer of injected oocytes into the fallopian tubes.”Design: Prospective randomized clinical trial. Setting: Te...Objective: To assess whether pregnancy rate differs in unilateral vs bilateral transfer in “immediate transfer of injected oocytes into the fallopian tubes.”Design: Prospective randomized clinical trial. Setting: Tertiary university hospital. Patient(s): The study population included 160 patients presenting with male factor infertility who fulfilled the criteria for immediate transfer of injected oocytes into tubes. Intervention(s): Four injected oocytes were transferred into two tubes (study group) or one tube (control group). Main Outcome Measure(s): Implantation rate, clinical pregnancy rate, multiple pregnancy rate, and incidence of pregnancy with unknown location (PUL). Result(s): A total of 72 (45%) pregnancies were achieved. There were 32 pregnancies (1 PUL, 4 multiple, and 27 singletons) in the bilateral transfer group and 40 pregnancies in the unilateral transfer group (1 PUL, 7 multiple, and 32 singletons). No significant difference was found in the implantation rate, clinical pregnancy rate, multiple pregnancy rate, and incidence of PUL. Conclusion( s): This study demonstrates that no difference in outcome occurred between unilateral and bilateral transfer in microinjected oocytes intrafallopian transfer (MIFT). Therefore, along with the same outcome parameters, unilateral transfer is the preferred method of MIFT.展开更多
Objective: To assess whether success rate differs in single-dose versus multiple-dose administration of methotrexate(MTX)-in medical management of unruptured ectopic pregnancies. Design: Prospective randomized clinica...Objective: To assess whether success rate differs in single-dose versus multiple-dose administration of methotrexate(MTX)-in medical management of unruptured ectopic pregnancies. Design: Prospective randomized clinical trial. Setting: Tertiary university hospital. Patient(s): The study population included 108 patients presenting with unruptured ectopic pregnancies who fulfilled the criteria for medical management. Intervention(s): A single dose(study group) or multiple doses(control group) of MTX were administered IM. Main Outcome Measure(s): Success rate of medical management in each group. Result(s): Of the 54 patients on the single-dose protocol, treatment was considered successful in 48 patients(88.9%). Of the 54 patients on the multiple-dose protocol, 50 participants responded to the treatment(92.6%). The diffe- rence between success rates in the two groups was not statistically significant(P=.7; odds ratio 0.64; 95%confidence interval 0.17-2.4). In the single-dose and multiple-dose groups, 15(27.8%) and 20(37%) patients, respectively, had complications(P=.3). Conclusion(s): The results of our study showed that single-dose treatment with MTX could be as successful as multiple doses. The incidence of complications did not differ between the two groups. It appears that single-dose treatment could be the first line of treatment in selected patients.展开更多
文摘Objective: To assess whether pregnancy rate differs in unilateral vs bilateral transfer in “immediate transfer of injected oocytes into the fallopian tubes.”Design: Prospective randomized clinical trial. Setting: Tertiary university hospital. Patient(s): The study population included 160 patients presenting with male factor infertility who fulfilled the criteria for immediate transfer of injected oocytes into tubes. Intervention(s): Four injected oocytes were transferred into two tubes (study group) or one tube (control group). Main Outcome Measure(s): Implantation rate, clinical pregnancy rate, multiple pregnancy rate, and incidence of pregnancy with unknown location (PUL). Result(s): A total of 72 (45%) pregnancies were achieved. There were 32 pregnancies (1 PUL, 4 multiple, and 27 singletons) in the bilateral transfer group and 40 pregnancies in the unilateral transfer group (1 PUL, 7 multiple, and 32 singletons). No significant difference was found in the implantation rate, clinical pregnancy rate, multiple pregnancy rate, and incidence of PUL. Conclusion( s): This study demonstrates that no difference in outcome occurred between unilateral and bilateral transfer in microinjected oocytes intrafallopian transfer (MIFT). Therefore, along with the same outcome parameters, unilateral transfer is the preferred method of MIFT.
文摘Objective: To assess whether success rate differs in single-dose versus multiple-dose administration of methotrexate(MTX)-in medical management of unruptured ectopic pregnancies. Design: Prospective randomized clinical trial. Setting: Tertiary university hospital. Patient(s): The study population included 108 patients presenting with unruptured ectopic pregnancies who fulfilled the criteria for medical management. Intervention(s): A single dose(study group) or multiple doses(control group) of MTX were administered IM. Main Outcome Measure(s): Success rate of medical management in each group. Result(s): Of the 54 patients on the single-dose protocol, treatment was considered successful in 48 patients(88.9%). Of the 54 patients on the multiple-dose protocol, 50 participants responded to the treatment(92.6%). The diffe- rence between success rates in the two groups was not statistically significant(P=.7; odds ratio 0.64; 95%confidence interval 0.17-2.4). In the single-dose and multiple-dose groups, 15(27.8%) and 20(37%) patients, respectively, had complications(P=.3). Conclusion(s): The results of our study showed that single-dose treatment with MTX could be as successful as multiple doses. The incidence of complications did not differ between the two groups. It appears that single-dose treatment could be the first line of treatment in selected patients.
