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Sex bias in response to hepatitis B vaccination in end-stage renal disease patients:Meta-analysis 被引量:1
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作者 Hossein Khedmat aghdas aghaei +1 位作者 Mohammad Ebrahim Ghamar-Chehreh Shahram Agah 《World Journal of Nephrology》 2016年第1期115-124,共10页
AIM: To systematically review the literature for studies investigating the potential effect of gender of dialysis patients on the immunogenicity of hepatitis B virus vaccines. METHODS: Literature searches were condu... AIM: To systematically review the literature for studies investigating the potential effect of gender of dialysis patients on the immunogenicity of hepatitis B virus vaccines. METHODS: Literature searches were conducted by the MEDLINE and Google Scholar. The key words used included “hepatitis B (HB)”, “vaccine”, “dialysis”, “hemodialysis”, “sex”, “male” and “female”. Data of seroresponse to HB vaccine in clinical trials regarding sex of the recipients have been achieved and analyzed. Finally data from 19 clinical trials have been pooled and analyzed.RESULTS: Analysis of response to HB vaccination in our dialysis population showed males significantly res-pond less to hepatitis B vaccination (P = 0.002, Z = 3.08) with no significant heterogeneity detected [P = 0.766; heterogeneity χ2 = 14.30 (df = 19); I2 = 0%]. A reanalysis of the pooled data was conducted regarding the dialysis mode to evaluate potential differential impact of sex on HB vaccine response. Hemodialysis was the only subgroup that showed a signifcant difference regarding dialysis mode in response to HB vaccination regarding sex ( P = 0.042, Z = 2.03).CONCLUSION: This Meta-analysis showed significant effect for the sex of chronic kidney disease and dialysis patients on the immunogenicity of HB vaccine. This sex discrimination was most prominent among hemodialysis patients. 展开更多
关键词 Hepatitis B virus vaccination Hepatitis B virus IMMUNOGENICITY Dialysis patients GENDER SEX
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