Systematic understanding of the underlying target and mechanism of sanguinarine against nasopharyngeal carcinoma through a networkpharmacology approach

Background:Nasopharyngeal carcinoma is a malignant tumor,well known as a cancer type characterized by regional specificity,especially in Southern China.The network pharmacology is an emerging discipline developed in recent years,which has been effectively used to predict the potential therapeutic compounds against disease focusing on the possible therapeutic targets and mechanisms.Sanguinarine,a traditional natural plant-derived phenanthridine alkaloid,has been reported to have a wide variety of pharmacological activities for decades.Methods:In the current study,using the comprehensive network pharmacological method,the potential drug targets of sanguinarine against nasopharyngeal carcinoma were successfully predicted,and verified by molecular docking.The underlying pharmacological mechanism was initially unraveled.Results:Totally,38 potential common targets were confirmed from these potential nasopharyngeal carcinoma therapeutic targets and pharmacological targets of sanguinarine.Their enrichment analyses of GO functions show that protein serine/threonine kinase activity,histone kinase activity,integrin binding,protein tyrosine kinase activity,and cell adhesion molecule binding were top listed.KEGG functional enrichment analysis indicates that the potential pathways are mainly involved into PI3K-Akt signaling pathway.The"drug-target-disease-pathway"network model diagram points out the key genes containing MAPK10,MAPK14,JAK2,BRAF,GSK3B,MET,HSP90AA1,SRC,et al..According to the results of molecular docking,it was further verified that sanguinarine has strong binding ability with MAPK10 and MAPK14.Conclusion:Taken together,this study would provide a clarified theoretical basis for the subsequent wet laboratory research focusing on sanguinarine against nasopharyngeal carcinoma.

Perovskite fluoride NaNiF_(3) with hollow micron sphere structure as anode for Li-ion hybrid capacitors

Lithium-ion hybrid capacitors(LIHCs) are gaining more attention and applications because they break the performance limitations of supercapacitors(SCs) and lithium-ion batteries(LIBs).However,the difference of energy storage mechanism between anode and cathode is a problem that must be faced by Li-ion hybrid capacitors.The selection of suitable anode and cathode materials is one of the effective ways to solve this problem.Here,we synthesized hollow spherical perovskite fluoride NaNiF3 by a simple and safe method.The specific capacity of NaNiF3 is 142 mAh·g^(-1) at 0.1 A·g^(-1) for 1000 cycles.The mechanism in the cycling of NaNiF3 electrodes was investigated using ex situ X-ray photoelectron spectroscopy(XPS),which is typical of the conversion reaction.Meanwhile,the NaNiF_(3)//activated carbon(AC) Li-ion hybrid capacitor assembled and showed better energy density(69 Wh·kg^(-1)) and power density(5699 W·kg^(-1)).Its capacity retention after long cycling was 79%.The use of NaNiF3 expands the choice of electrode materials for LIHCs and extends their practical applications.