A Multi-Task Motion Generation Model that Fuses a Discriminator and a Generator

The human motion generation model can extract structural features from existing human motion capture data,and the generated data makes animated characters move.The 3D human motion capture sequences contain complex spatial-temporal structures,and the deep learning model can fully describe the potential semantic structure of human motion.To improve the authenticity of the generated human motion sequences,we propose a multi-task motion generation model that consists of a discriminator and a generator.The discriminator classifies motion sequences into different styles according to their similarity to the mean spatial-temporal templates from motion sequences of 17 crucial human joints in three-freedom degrees.And target motion sequences are created with these styles by the generator.Unlike traditional related works,our model can handle multiple tasks,such as identifying styles and generating data.In addition,by extracting 17 crucial joints from 29 human joints,our model avoids data redundancy and improves the accuracy of model recognition.The experimental results show that the discriminator of the model can effectively recognize diversified movements,and the generated data can correctly fit the actual data.The combination of discriminator and generator solves the problem of low reuse rate of motion data,and the generated motion sequences are more suitable for actual movement.

Efficient Regeneration and Agrobacterium-mediated Transformation of Brassica napus Cultivar Qingza No.5

Using the hypocotyl and cotyledon explants of Brassica napus L. cuhivar Qingza No. 5 as receptors, hormone combinations in bud differentiation medi- um, bud growth medium and rooting medium were optimized to establish an efficient plantlet regeneration system of B. napus cuhivar Qingza No. 5. The results showed that the highest differentiation efficiency of hypocotyls of B. napus cuhivar Qingza No. 5 reached about 90%, which was three times that of cotyledons. The appropriate differentiation medium was MSB ＋ 5 mg/L thidiazuron （TDZ） ＋7.5 mg/L AgNO3 ＋ 0.1 mg/L NAA ＋ 2 mg/L proline （L-pro） ＋ 250 mg/L casein acid hydrolysate （CH） ＋ 3% sucrose; the appropriate growth medium was 1/2 MSB ＋ 1 mg/L IBA ＋ 2 mg/L L-pro ＋ 250 mg/L CH ＋ 1.5% sucrose; the ap- propriate rooting medium was 1/2 MSB ＋ 0.2 mg/L IAA ＋ 1.5% sucrose. On this basis, a binary expression vector harboring insect resistance gene B12 was constructed and introduced into B. napus hypocotyls by Agrobacterium-mediated transformation. Positive plants were screened using hygromycin and carbenicillin. Transgenic plants were verified by PCR and GUS histochemical staining. The results showed that insect resistance gene B12 was successfully integrated into the nu- clear genome of B. napus plants and could be expressed normally. Leaves of transgenic plants with high expression levels were collected for indoor inoculation test with Plutella xylotella larvae to evaluate insect resistance of transgenic plants.

Developing Rural Cooperative Finance with Reference to Experience of Foreign Countries

At present,rural credit cooperative is an essential part of rural financial system in China. Since the foundation of new China,especially since the reform and opening-up,rural credit cooperative has become the largest financial organization in rural areas. However,its operation mode needs further improvement and service functions are to be strengthened. Therefore,learning successful mode of rural cooperative finance in foreign countries has important theoretical and realistic significance for promoting development of China's rural cooperative finance.

A rationally designed cancer vaccine based on NIR-II fluorescence image-guided light-triggered remote control of antigen cross-presentation and autophagy

Cancer vaccines represent a promising immunotherapeutic treatment modality.The promotion of cross-presentation of extracellular tumor-associated antigens on the major histocompatibility complex(MHC) class I molecules and dendritic cell maturation at the appropriate time and place is crucial for cancer vaccines to prime cytolytic T cell response with reduced side effects.Current vaccination strategies,however,are not able to achieve the spatiotemporal control of antigen cross-presentation.Here,we report a liposomal vaccine loading the second near-infrared window(NIR-II,1000—1700 nm) fluorophore BPBBT with an efficient photothermal conversion effect that offers an NIR-light-triggered endolysosomal escape under the imaging guidance.The NIR-II image-guided vaccination strategy specifically controls the cytosolic delivery of antigens for cross-presentation in the draining lymph nodes(DLNs).Moreover,the photothermally induced endolysosomal rupture initiates autophagy.We also find that the adjuvant simvastatin acts as an autophagy activator through inhibiting the PI3K/AKT/m TOR pathway.The light-induced autophagy in the DLNs together with simvastatin treatment cooperatively increase MHC class II expression by activating autophagy machinery for dendritic cell maturation.This study presents a paradigm of NIR-II image-guided light-triggered vaccination.The approach for remote control of antigen cross-presentation and autophagy represents a new strategy for vaccine development.

原料形貌特性和高温梯度碳化工艺对纳米WC粉末及其WC-Co合金均匀性的影响

采用不同氧化钨原料,通过氢还原、高温碳化工艺制备纳米W、WC粉末,研究了氧化钨形貌特性对纳米W、WC粉体形貌、均匀性的影响。择优选取了高比表面特制蓝钨(SBTO),并结合新型高温梯度碳化工艺制备了纳米碳化钨粉末,研究了新型高温梯度碳化工艺对纳米WC粉体特性及超细晶WC-Co硬质合金性能的影响。通过比表面测定仪、费氏粒度仪、定碳仪测定了粉体的比表面、粒度、总碳等,用扫描电镜(SEM)观察了粉末的形貌和合金的显微组织,同时按WC-Co硬质合金相关测试标准对烧结试样的性能进行了检测、分析。结果表明,颗粒均匀、比表面积大,具有疏松、多空隙形貌结构的氧化钨粉末,利于制备出颗粒均匀、分散性好的纳米W粉和WC粉;晶粒聚集和异常粗大颗粒的产生,与碳化过程中团聚纳米钨粉颗粒因烧结合并增粗有关,而高温梯度碳化能有效抑制此类现象的发生;采用特制蓝钨(SBTO)和高温梯度碳化工艺的良好结合,可以制备出具有均匀组织结构的高性能超细晶WC-Co硬质合金。

Genetically-engineered“all-in-one”vaccine platform for cancer immunotherapy

An essential step for cancer vaccination is to break the immunosuppression and elicit a tumor-specific immunity.A major hurdle against cancer therapeutic vaccination is the insufficient immune stimulation of the cancer vaccines and lack of a safe and efficient adjuvant for human use.We discovered a novel cancer immunostimulant,trichosanthin(TCS),that is a clinically used protein drug in China,and developed a well-adaptable protein-engineering method for making recombinant protein vaccines by fusion of an antigenic peptide,TCS,and a cell-penetrating peptide(CPP),termed an"allin-one"vaccine,for transcutaneous cancer immunization.The TCS adjuvant effect on antigen presentation was investigated and the antitumor immunity of the vaccines was investigated using the different tumor models.The vaccines were prepared via a facile recombinant method.The vaccines induced the maturation of DCs that subsequently primed CD8^(+)T cells.The TCS-based immunostimulation was associated with the STING pathway.The general applicability of this genetic engineering strategy was demonstrated with various tumor antigens(i.e.,legumain and TRP2 antigenic peptides)and tumor models(i.e.,colon tumor and melanoma).These findings represent a useful protocol for developing cancer vaccines at low cost and time-saving,and demonstrates the adjuvant application of TCSdan old drug for a new application.

纳米强化片状W/Co/C复合粉末的制备与烧结体性能

采用高效球磨细氧化钨、扁平片状W粉、碳黑、钴及适量晶粒长大抑制剂等为原料,通过碳辅助氢还原制备质量分数20%纳米钨强化片状W/Co/C复合粉末,于低压真空烧结炉中在1410℃的温度下一次碳化烧结,制备了含片状晶WC-10%Co(质量分数)硬质合金,研究了质量分数20%纳米W的引入对合金烧结致密化及其性能的影响。对不同粉体的比表面、费氏粒度进行了测定,观察了粉体的颗粒形貌和WC-Co烧结体的显微组织,同时按硬质合金性能测试标准检测了烧结体的物理、力学性能。结果表明,采用质量分数20%纳米钨强化片状W/Co/C复合粉末,经一次碳化烧结可制备出致密化程度高的含片状晶WC-Co硬质合金;质量分数20%纳米W粉的引入利于压坯烧结收缩致密化,促进片状WC晶粒的生成,不仅有利于合金硬度(耐磨性)的提高,还因裂纹扩展机制的变化,合金的断裂韧性明显改善。

触须样免疫性肾小球病:1例报告并文献复习

触须样免疫性肾小球病(immunotactoid glomerulopathy, ITG)是一种罕见的肾脏疾病,国内外文献中报道的病例数不足100例[1]。肾脏病理电镜观察可见特征性中空微管结构沉积在系膜区和基底膜内,少见肾外系统受累。其发病机制仍不清楚,可能与浆细胞或B淋巴细胞异常增殖相关,常继发于血液系统疾病[2]。近年来的研究强调靶向浆细胞或B淋巴细胞治疗ITG,较少关注糖皮质激素对ITG的作用。本文报道1例ITG,探讨了本病的临床表现、病理特征、诊断和治疗等。