GPS monitoring and analysis of ground movement and deformation induced by transition from open-pit to underground mining

To trace the potential hazards of open-pit slope in Longshou mine,global positioning system（GPS） is applied to monitoring ground movement and deformation induced by transition from open-pit to underground mining.Through long-term monitoring from 2003 to 2008,huge amounts of data were acquired.Monitoring results show that large-scale ground movement and deformation have occurred in mining area,and the movement area is ellipse-shaped.The displacement boundary of settlement trough is 2.0 km long along the exploratory line,and 1.5 km long along the strike of ore body.GPS monitoring results basically agree with the practical deformation state of open-pit slope.It is indicated that the long-term GPS monitoring is an effective way to understand the mechanism of ground movement and deformation in mine area. 更多

Toxic epidermal necrosis caused by programmed cell death protein 1 inhibitors in a patient receiving chimeric antigen receptor-T cell therapy

To the Editor:Toxic epidermal necrosis(TEN)is a severe dermal-mucous reaction characterized by rashes,blisters,and a generalized laxity of the epidermis.[1]Blockade of the programmed cell death protein 1(PD-1)/programmed cell death 1 ligand 1(PD-L1)pathway could activate and proliferate auto-reactive CD8+T-cells,which is a crucial step in TEN.The efficacy of anti-CD19 chimeric antigen receptor-T(CAR-T)cells can be inhibited by activating the PD-1/PD-L1 pathway.[2]As a result,the combination of PD-1 blockade and CAR-T cell therapy would increase the functions of CAR-T cells.[3]This case report describes a patient with refractory diffuse large B-cell lymphoma(DLBCL)who had severe TEN after CAR-T cell therapy and PD-1 blockade.

Hydrochemical Characteristics and the Suitability of Groundwater in the Coastal Region of Tangshan, China

Through collecting groundwater samples from the coastal region of Tangshan, China, the hydrochemical processes that affect the chemical composition of groundwater and the quality of resources were analyzed. Chemical constituents, factor analysis, and a graphic method were employed in this research. The results show that human activities obviously affect fresh groundwater. The deep groundwater distributed in the southern part of the region is severely affected by salinization, and the shallow groundwater in the north is also beginning to show the same deterioration. The chemical concentrations of the deep groundwater depend largely upon the water-rock interaction, the mixing of saline water and the ion exchange processes. With the exception of sample C-33, all the groundwater samples in the study area are suitable for drinking. Tests show that roughly half of the deep groundwater samples have at least one water quality index indicating that it is chemically doubtful or unsuitable for irrigation. Therefore, it is concluded that deep groundwater is becoming an unacceptable resource to irrigate areas located near the coastline because the groundwater quality in the study area is exhibiting signs of degradation. This study＇s findings contribute to a better understanding of groundwater resources in order to support regional management and protection.

Clinical feature and waveform in infantile nystagmus syndrome in children with FRMD7 gene mutations

Infant nystagmus sydrome presents as involuntary eye movement disorder and can affect seriously ocular function. We performed a retrospective study of clinical data and FRMD7 genetic test results in 12 cases of infantile nystagmus syndrome to correlate waveform, stereopsis, and visual acuity. The patients(age 6.40±2.67 years) had FRMD7 mutations as follows: missense in eight cases, shear in two cases, frameshift in one case, and non-frameshift in one case. Horizontal jerk waveform was observed in six cases, versus horizontal pendulum in five cases and dual jerk in one case. The uncorrected visual acuity(24 eyes) was 0.21±0.12,compared with a corrected visual acuity(24 eyes) of 0.32±0.14. All patients had simultaneous perception, versus fusion function in 10 cases(83.33%) and stereoscopic vision in seven cases(58.33%) using the synoptophore. Eleven cases(91.67%) detected the stereo fly, compared with five cases(41.67%) for stereoscopic circles and seven cases(58.33%) for stereoscopic animals by Titmus test. Stereoscopic vision using the synoptophore did not correlate with the frequency, amplitude, or intensity of nystagmus or with corrected binocular visual acuity. The infantile nystagmus syndrome with FRMD7 mutations in our cases was caused primarily de novo and missense mutations. Visual acuity and binocular visual function were significant impaired, and the waveform was generally horizontal jerk. Also, an infrared videonystagmogram can record the frequency, amplitude, and intensity of nystagmus accurately.