Congenital diaphragmatic hernia(CDH)is a major congenital anomaly,resulting from the herniation of abdominal contents into the thoracic cavity,thereby impeding the proper development of the lungs and pulmonary vascula...Congenital diaphragmatic hernia(CDH)is a major congenital anomaly,resulting from the herniation of abdominal contents into the thoracic cavity,thereby impeding the proper development of the lungs and pulmonary vasculature.CDH severity correlates with a spectrum of pulmonary hypoplasia,pulmonary hypertension(PHT),and cardiac dysfunction,constituting the pathophysiological triad of this complex condition.The accurate diagnosis and effective management of PHT and cardiac dysfunction is pivotal to optimizing patient outcomes.Targeted neonatal echocardiography is instrumental in delivering real-time data crucial for the bespoke,pathophysiology-targeted hemodynamic management of CDH-associated PHT.展开更多
Background Acetaminophen use for pharmacological treatment of hemodynamically significant patent ductus arteriosus(hsPDA)in preterm infants is becoming more popular with emerging evidence that it is effective as well ...Background Acetaminophen use for pharmacological treatment of hemodynamically significant patent ductus arteriosus(hsPDA)in preterm infants is becoming more popular with emerging evidence that it is effective as well as safe alternative for other agents used to close hsPDA.Data sources We performed a narrative review of literature about pharmacological treatment of PDA using acetaminophen.Results Acetaminophen was used as a prophylaxis,symptomatic,targeted,and a rescue approach.Conclusions It appears that acetaminophen could be used in different approaches to close the hsPDA.Long-term outcomes of acetaminophen exposure early in life still lack certainty.展开更多
基金JYT holds the endowed Variety,the Children's Charity,and the Stollery Children's Hospital Foundation Pediatric Clinical Research Professorship,with funding support from Women and Children's Health Research Institute and Faculty of Medicine&Dentistry,University of Alberta.
文摘Congenital diaphragmatic hernia(CDH)is a major congenital anomaly,resulting from the herniation of abdominal contents into the thoracic cavity,thereby impeding the proper development of the lungs and pulmonary vasculature.CDH severity correlates with a spectrum of pulmonary hypoplasia,pulmonary hypertension(PHT),and cardiac dysfunction,constituting the pathophysiological triad of this complex condition.The accurate diagnosis and effective management of PHT and cardiac dysfunction is pivotal to optimizing patient outcomes.Targeted neonatal echocardiography is instrumental in delivering real-time data crucial for the bespoke,pathophysiology-targeted hemodynamic management of CDH-associated PHT.
文摘Background Acetaminophen use for pharmacological treatment of hemodynamically significant patent ductus arteriosus(hsPDA)in preterm infants is becoming more popular with emerging evidence that it is effective as well as safe alternative for other agents used to close hsPDA.Data sources We performed a narrative review of literature about pharmacological treatment of PDA using acetaminophen.Results Acetaminophen was used as a prophylaxis,symptomatic,targeted,and a rescue approach.Conclusions It appears that acetaminophen could be used in different approaches to close the hsPDA.Long-term outcomes of acetaminophen exposure early in life still lack certainty.
