Objective: To evaluate the efficacy and safety of icotinib hydrochloride in patients with advanced non-small cell lung cancer (NSCLC). Methods: A total of 89 patients with stage IIIB or IV NSCLC received icotinib ...Objective: To evaluate the efficacy and safety of icotinib hydrochloride in patients with advanced non-small cell lung cancer (NSCLC). Methods: A total of 89 patients with stage IIIB or IV NSCLC received icotinib at a dose of 125 mg administered 3 times a day. Icotinib treatment was continued until disease progression or development of unacceptable toxicity. Results: A total of 89 patients were assessable. In patients treated with icotinib, the overall response rate (RR) was 36.0% (32/89), and the disease control rate (DCR) was 69.7% (62/89). RR and DCR were significantly improved in patients with adenocarcinoma versus non-adenocarcinoma (P〈0.05). The symptom improvement rate was 57.3% (51/89), and the main symptoms improved were cough, pain, chest distress, dyspnea, and Eastern Cooperative Oncology Group performance status. The main toxic effects were rash [30/89 (33.7%)] and diarrhea [15/89 (16.9%)]. The level of toxicity was typically low. Conclusions: The use of icofinib hydrochloride in the treatment of advanced NSCLC is efficacious and safe, and its toxic effects are tolerable.展开更多
Objective: To investigate the expressions and the clinical significance of P53, C-erbB-2 and vascular endothelial growth factor (VEGF) in non-small cell lung cancer (NSCLC). Methods: 121 specimens of NSCLC were examin...Objective: To investigate the expressions and the clinical significance of P53, C-erbB-2 and vascular endothelial growth factor (VEGF) in non-small cell lung cancer (NSCLC). Methods: 121 specimens of NSCLC were examined for P53, C-erbB-2 and VEGF by immunohistochemical staining. Results: The positive rates of P53, C-erbB-2 and VEGF in the carci- nomatous tissue were 43%, 39% and 31% respectively. P53 gene protein expression in lung cancer was significantly related to histological type and P-TNM staging of lung cancer patients (P < 0.05), and was not associated with the sex, age, the size of primary cancer, lymph node metastasis and cell differentiation (P > 0.05). C-erbB-2 gene protein expression in lung cancer was closely related to histological type and cell differentiation (P < 0.05), and was not associated with the sex, age, the size of primary cancer, lymph node metastasis and P-TNM staging of lung cancer patients (P > 0.05). VEGF in lung cancer was only closely related to cell differentiation (P < 0.05), and was not associated with the sex, age, the size of primary cancer, lymph node metastasis, histological type and P-TNM staging of lung cancer patients (P > 0.05). Conclusion: It is possible for P53, C-erbB-2 and VEGF to play an important role in the oncogenesis and development of non-small cell lung cancer.展开更多
Summary What is already known about this topic?Healthcare workers(HCWs)and previously infected patients(PIPs)may experience a wave of epidemic following the modification of the country’s coronavirus disease(COVID)-ze...Summary What is already known about this topic?Healthcare workers(HCWs)and previously infected patients(PIPs)may experience a wave of epidemic following the modification of the country’s coronavirus disease(COVID)-zero policy in China.What is added by this report?As of early January 2023,the initial wave of the COVID-19 pandemic among HCWs had effectively subsided,with no statistically significant differences observed in infection rates compared to those of their co-occupants.The proportion of reinfections among PIPs was relatively low,particularly in those with recent infections.What are the implications for public health practice?Medical and health services have resumed normal operations.For patients who have recently experienced severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infections,appropriate relaxation of policies may be considered.展开更多
文摘Objective: To evaluate the efficacy and safety of icotinib hydrochloride in patients with advanced non-small cell lung cancer (NSCLC). Methods: A total of 89 patients with stage IIIB or IV NSCLC received icotinib at a dose of 125 mg administered 3 times a day. Icotinib treatment was continued until disease progression or development of unacceptable toxicity. Results: A total of 89 patients were assessable. In patients treated with icotinib, the overall response rate (RR) was 36.0% (32/89), and the disease control rate (DCR) was 69.7% (62/89). RR and DCR were significantly improved in patients with adenocarcinoma versus non-adenocarcinoma (P〈0.05). The symptom improvement rate was 57.3% (51/89), and the main symptoms improved were cough, pain, chest distress, dyspnea, and Eastern Cooperative Oncology Group performance status. The main toxic effects were rash [30/89 (33.7%)] and diarrhea [15/89 (16.9%)]. The level of toxicity was typically low. Conclusions: The use of icofinib hydrochloride in the treatment of advanced NSCLC is efficacious and safe, and its toxic effects are tolerable.
文摘Objective: To investigate the expressions and the clinical significance of P53, C-erbB-2 and vascular endothelial growth factor (VEGF) in non-small cell lung cancer (NSCLC). Methods: 121 specimens of NSCLC were examined for P53, C-erbB-2 and VEGF by immunohistochemical staining. Results: The positive rates of P53, C-erbB-2 and VEGF in the carci- nomatous tissue were 43%, 39% and 31% respectively. P53 gene protein expression in lung cancer was significantly related to histological type and P-TNM staging of lung cancer patients (P < 0.05), and was not associated with the sex, age, the size of primary cancer, lymph node metastasis and cell differentiation (P > 0.05). C-erbB-2 gene protein expression in lung cancer was closely related to histological type and cell differentiation (P < 0.05), and was not associated with the sex, age, the size of primary cancer, lymph node metastasis and P-TNM staging of lung cancer patients (P > 0.05). VEGF in lung cancer was only closely related to cell differentiation (P < 0.05), and was not associated with the sex, age, the size of primary cancer, lymph node metastasis, histological type and P-TNM staging of lung cancer patients (P > 0.05). Conclusion: It is possible for P53, C-erbB-2 and VEGF to play an important role in the oncogenesis and development of non-small cell lung cancer.
基金Supported by Jiangsu Medical Innovation Team(CXTDB2017015)Taizhou People’s Hospital Medical Innovation Team Foundation(CXTDA201901,CXTDA201904,Class A)Taizhou People's Hospital Scientific Research Foundation(ZL202020,Vaccination).
文摘Summary What is already known about this topic?Healthcare workers(HCWs)and previously infected patients(PIPs)may experience a wave of epidemic following the modification of the country’s coronavirus disease(COVID)-zero policy in China.What is added by this report?As of early January 2023,the initial wave of the COVID-19 pandemic among HCWs had effectively subsided,with no statistically significant differences observed in infection rates compared to those of their co-occupants.The proportion of reinfections among PIPs was relatively low,particularly in those with recent infections.What are the implications for public health practice?Medical and health services have resumed normal operations.For patients who have recently experienced severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infections,appropriate relaxation of policies may be considered.