Neutrosophic N-Structures Applied to Sheffer Stroke BL-Algebras

In this paper,we introduce a neutrosophic N-subalgebra,a(ultra)neutrosophic N-filter,level sets of these neutrosophic N-structures and their properties on a Sheffer stroke BL-algebra.By defining a quasi-subalgebra of a Sheffer stroke BL-algebra,it is proved that the level set of neutrosophic N-subalgebras on the algebraic structure is its quasi-subalgebra and vice versa.Then we show that the family of all neutrosophic N-subalgebras of a Sheffer stroke BL-algebra forms a complete distributive lattice.After that a(ultra)neutrosophic N-filter of a Sheffer stroke BL-algebra is described,we demonstrate that every neutrosophic N-filter of a Sheffer stroke BL-algebra is its neutrosophic N-subalgebra but the inverse is generally not true.Finally,it is presented that a level set of a(ultra)neutrosophic N-filter of a Sheffer stroke BL-algebra is also its(ultra)filter and the inverse is always true.Moreover,some features of neutrosophic N-structures on a Sheffer stroke BL-algebra are investigated.

Synthesis and Physicochemical Characterization of Biodegradable Star-Shaped Poly Lactide-Co-Glycolide-<i>β</i>-Cyclodextrin Copolymer Nanoparticles Containing Albumin

The purposes of this research were to synthesize and characterize star-shaped poly lactide-co-glycolide-β-cyclo-dextrin (PLGA-β-CD) copolymer by reacting L-lactide, glycolide and β-cyclodextrin in the presence of stannous octoate as a catalyst. The structure of PLGA-β-CD copolymer was confirmed with 1H-NMR, 13C-NMR and FT-IR spectra. Albumin as a model peptide drug was encapsulated within nanoparticles made of PLGA-β-CD with a modified double emulsion method. Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) photomicrographs showed that the nanoparticles have the mean diameter within the range of 80 - 210 nm. Also they were almost spherical in shape. Effects of the experimental parameters, such as copolymer composition, copolymer concentration, and reaction temperature, on particular size and encapsulation efficiency were investigated.

<i>In Vitro</i>Studies of NIPAAM-MAA-VP Copolymer-Coated Magnetic Nanoparticles for Controlled Anticancer Drug Release

Thermosensetive poly(N-isopropylacrylamide)-based magnetic nanoparticles were synthesized by free radical polymerization of N-isopropylacrylamide (NIPPAMs), methacrylic acid (MAA), and vinyl pyrrolidone (VP) in the presence of methylene-bis-acrylamide as cross linking agent. The Fe3O4 magnetic nanoparticls were prepared by chemical precipitation of Fe salts in the ratio of 1:2 under alkaline and inert condition. Thermosensitive crosslinked P (NI-PAAM-MAA-VP) copolymers were characterized by FT-IR and H-NMR. The pH and thermosensitive copolymer was used for preparation of drug loaded magnetic nanoparticles, and doxorubicin (DOX) was used as a typical anticancer drug. The amount of the loaded drug and drug release amount were determined by UV measurements. Scanning electron microscopy (SEM) and lower critical solution temperature (LCST) were used to determine the particle surface morphology and the phase transition temperature of the nanoparticles respectively. The release behavior of DOX at pH = 7.4 and 37°C was studied. The result indicated that this thermosensetive magnetic nanoparticle has a high drug loading capacity and favorable linear release property for DOX without initial burst release. Thus this system is promising for the application in targeted smart anticancer drug delivery.