Evaluation of a Barrier Repair Cream Containing Pseudo-Ceramide for Practical Use by Hairdressers with Hand Skin Disorders Due to Daily Exposure to Chemical Irritants

Hairdressers are exposed to numerous skin-damaging factors, such as wet work, skin irritants, and thermal changes. Skin protection is a very important factor for the prevention of occupational skin disorders. Therefore, we evaluated a hand cream that was specially formulated for highly stressed skin with regard to its capability to reduce dry, rough, and scaly skin. The objective of this study was to conduct a controlled use test of a barrier repair cream containing pseudo-ceramide and demonstrate its efficacy for hairdressers with dry, sensitive hands and/or occupational skin disorders. A total of 30 hairdressers (29 females and 1 male, aged 20 - 67) participated in the study. All subjects suffered from dry hands. Subjects applied the test cream on their hands for 28 days (four weeks). For each subject, the skin surface topography of the hands was measured by the Surface Evaluation of Living Skin (SELS) system at day 14 (week 2) and day 28 (week 4). Dryness, scaling, cracking, redness, and itchiness were evaluated and graded by experts at week 2 and week 4, and then compared to baselines. All 30 subjects completed the study. A comparison of the changes from baseline to endpoint revealed a statistically significant reduction in skin roughness, scaling, and volume measured according to SELS. These data were confirmed by photographic documentation. The results were further supported by the expert evaluation. For the symptoms dryness and scaling, improvement could be observed in almost all regions of the hands. In addition, according to subjective assessments of overall hand skin condition and the hand cream, subjects reported clear improvement over time (p value below 0.001) and good efficacy of the product. In this study, the test hand cream showed excellent skin compatibility. Therefore, the hand cream may be effective for hairdressers with dry, sensitive hands and/or occupational skin disorders.

Efficacy Evaluation of Unique Skincare Product Containing Pseudo-Ceramide for Fine Wrinkles in Japanese Female Atopic Dermatitis Patients

Background/Objective: Dryness is considered to be an early developmental mechanism of wrinkles, and fine line formation is marked in atopic dermatitis (AD) accompanied by dry skin. To evaluate the efficacy of a skincare product with a moisturizing effect increased by lamellar formulation of pseudo-ceramide for fine lines and wrinkles, a use test was performed applying the product to non-lesional dry skin in patients with atopic dermatitis. Method: The test product was an essence containing pseudo-ceramide formulated in a lamellar structure. The study design was a nine-week single-center non-comparative study, and the evaluation items were the grade of wrinkles at the corners of the eyes judged by a dermatologist, replica analysis, and instrumental measurement (skin surface moisture and transepidermal water loss). Results: Nine-week continuous use of the test product significantly improved the score of wrinkles at the corners of the eyes judged by a dermatologist and wrinkle area ratio on replica analysis of the corners of the eyes and cheeks, compared with those at study initiation. With this improvement, the losses of skin surface moisture and transepidermal water were also significantly improved. Conclusion: It was clarified that the tested pseudo-ceramide-formulated skincare product not only improved the barrier function for atopic dermatitis, but also exhibited an effect on fine lines and wrinkles of dry skin.

使用蒙特卡罗模型分析^111In对^90Y韧致辐射SPECT显像的影响

【摘要】目的用于治疗恶性淋巴瘤的^90Y-替伊莫单克隆抗体（^90Y—Zevalin，^90Y-泽娃灵）由于^90Y衰变放出的β粒子具有韧致辐射，故可用于SPECT显像。但使用如Y-泽娃灵前，会行^111In-泽娃灵显像以判断是否为^90Y-泽娃灵治疗的适应证，而^111In-泽娃灵发出的γ射线会干扰^90Y的韧致辐射显像。