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Case series of three patients with hereditary diffuse gastric cancer in a single family:Three case reports and review of literature
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作者 Masahiro Hirakawa Kohichi Takada +14 位作者 Masanori Sato Chisa Fujita Naotaka Hayasaka Takayuki Nobuoka Shintaro Sugita Aki Ishikawa Miyako Mizukami Hiroyuki Ohnuma Kazuyuki Murase Koji Miyanishi Masayoshi Kobune Ichiro Takemasa Tadashi Hasegawa akihiro sakurai Junji Kato 《World Journal of Gastroenterology》 SCIE CAS 2020年第42期6689-6697,共9页
BACKGROUND Hereditary diffuse gastric cancer(HDGC)is a familial cancer syndrome often associated with germline mutations in the CDH1 gene.However,the frequency of CDH1 mutations is low in patients with HDGC in East As... BACKGROUND Hereditary diffuse gastric cancer(HDGC)is a familial cancer syndrome often associated with germline mutations in the CDH1 gene.However,the frequency of CDH1 mutations is low in patients with HDGC in East Asian countries.Herein,we report three cases of HDGC harboring a missense CDH1 variant,c.1679C>G,from a single Japanese family.CASE SUMMARY A 26-year-old female(Case 1)and a 51-year-old male(father of Case 1),who had a strong family history of gastric cancer,were diagnosed with advanced diffuse gastric cancer.After genetic counselling,a 25-year-old younger brother of Case 1 underwent surveillance esophagogastroduodenoscopy that detected small signet ring cell carcinoma foci as multiple pale lesions in the gastric mucosa.Genetic analysis revealed a CDH1 c.1679C>G variant in all three patients.CONCLUSION It is important for individuals suspected of having HDGC to be actively offered genetics evaluation.This report will contribute to an increased awareness of HDGC. 展开更多
关键词 Hereditary diffuse gastric cancer Signet ring cell carcinoma CDH1 Ecadherin Endoscopic findings Case report
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