A polarization control device was developed using a plasmonic metasurface with the aim of achieving the desired polarization state. In this study, the Ag metal grating structure was fabricated as a plasmonic metasurfa...A polarization control device was developed using a plasmonic metasurface with the aim of achieving the desired polarization state. In this study, the Ag metal grating structure was fabricated as a plasmonic metasurface by electron beam lithography and a lift-off process. The phase difference of the fabricated sample was 21.0°. This value is almost consistent with the simulation (24.0°). Then, the transmission and phase difference is dependent on the structural parameter. Because of the propagation of surface plasmon polariton at the interface between Ag and SiO<sub>2</sub> or Ag and air, it is believed that the transmittance and the phase difference for TM polarized light can be controlled by the structural parameters. By plotting on the Poincaré sphere after calculating the S-parameter by simulation, it is clear that the arbitrary polarization status can be controlled by the structural parameter.展开更多
AIM: To evaluate the dose-limiting toxicities(DLTs)and determine the maximum-tolerated dose(MTD) and recommended dose(RD) of combination chemotherapy with gemcitabine, cisplatin and S-1 which is an oral fluoropyrimidi...AIM: To evaluate the dose-limiting toxicities(DLTs)and determine the maximum-tolerated dose(MTD) and recommended dose(RD) of combination chemotherapy with gemcitabine, cisplatin and S-1 which is an oral fluoropyrimidine pro-drug in patients with advanced biliary tract cancer.METHODS: Patients with histologically or cytologically confirmed unresectable or recurrent biliary tract cancer were enrolled. The planned dose levels of gemcitabine(mg/m2), cisplatin(mg/m2), and S-1(mg/m2 per day) were as follows: level-1, 800/20/60;level 0, 800/25/60; level 1, 1000/25/60; and level 2,1000/25/80. In each cycle, gemcitabine and cisplatin were administered intravenously on days 1 and 15,and S-1 was administered orally twice daily on days 1to 7 and days 15 to 21, every 4 wk.RESULTS: Twelve patients were enrolled, and level0 was chosen as the starting dose. None of the first three patients had DLTs at level 0, and the dose was escalated to level 1. One of six patients had DLTs(grade 4 febrile neutropenia, leucopenia, and neutropenia; grade 3 thrombocytopenia) at level 1.We then proceeded to level 2. None of three patients had DLTs during the first cycle. Although the MTD was not determined, level 2 was designated at the RD for a subsequent phase Ⅱ study.CONCLUSION: The RD was defined as gemcitabine1000 mg/m2(days 1, 15), cisplatin 25 mg/m2(days1, 15), and S-1 80 mg/m2 per day(days 1-7, 15-21),every 4 weeks. A phase Ⅱ study is planned to evaluate the effectiveness of combination chemotherapy withgemcitabine, cisplatin, and S-1 in advanced biliary tract cancer.展开更多
文摘A polarization control device was developed using a plasmonic metasurface with the aim of achieving the desired polarization state. In this study, the Ag metal grating structure was fabricated as a plasmonic metasurface by electron beam lithography and a lift-off process. The phase difference of the fabricated sample was 21.0°. This value is almost consistent with the simulation (24.0°). Then, the transmission and phase difference is dependent on the structural parameter. Because of the propagation of surface plasmon polariton at the interface between Ag and SiO<sub>2</sub> or Ag and air, it is believed that the transmittance and the phase difference for TM polarized light can be controlled by the structural parameters. By plotting on the Poincaré sphere after calculating the S-parameter by simulation, it is clear that the arbitrary polarization status can be controlled by the structural parameter.
文摘AIM: To evaluate the dose-limiting toxicities(DLTs)and determine the maximum-tolerated dose(MTD) and recommended dose(RD) of combination chemotherapy with gemcitabine, cisplatin and S-1 which is an oral fluoropyrimidine pro-drug in patients with advanced biliary tract cancer.METHODS: Patients with histologically or cytologically confirmed unresectable or recurrent biliary tract cancer were enrolled. The planned dose levels of gemcitabine(mg/m2), cisplatin(mg/m2), and S-1(mg/m2 per day) were as follows: level-1, 800/20/60;level 0, 800/25/60; level 1, 1000/25/60; and level 2,1000/25/80. In each cycle, gemcitabine and cisplatin were administered intravenously on days 1 and 15,and S-1 was administered orally twice daily on days 1to 7 and days 15 to 21, every 4 wk.RESULTS: Twelve patients were enrolled, and level0 was chosen as the starting dose. None of the first three patients had DLTs at level 0, and the dose was escalated to level 1. One of six patients had DLTs(grade 4 febrile neutropenia, leucopenia, and neutropenia; grade 3 thrombocytopenia) at level 1.We then proceeded to level 2. None of three patients had DLTs during the first cycle. Although the MTD was not determined, level 2 was designated at the RD for a subsequent phase Ⅱ study.CONCLUSION: The RD was defined as gemcitabine1000 mg/m2(days 1, 15), cisplatin 25 mg/m2(days1, 15), and S-1 80 mg/m2 per day(days 1-7, 15-21),every 4 weeks. A phase Ⅱ study is planned to evaluate the effectiveness of combination chemotherapy withgemcitabine, cisplatin, and S-1 in advanced biliary tract cancer.
