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C反应蛋白确定损伤的严重程度:需外科手术的婴儿住院时间的预测指标
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作者 alaedeen d. i. Queen A. L. +2 位作者 Leung E. W. J. Chwals 李丹 《世界核心医学期刊文摘(儿科学分册)》 2005年第5期55-56,共2页
Background/Purpose Serum C-reactive protein (CRP) levels reflect the severity of the metabolic response to injury in critically ill children. During this per iod, caloric overfeeding can increase complications and del... Background/Purpose Serum C-reactive protein (CRP) levels reflect the severity of the metabolic response to injury in critically ill children. During this per iod, caloric overfeeding can increase complications and delay recovery. The auth ors hypothesized that by avoiding excessive caloric delivery, the effect of inju ry severity would be the major factor determining clinical outcome. Methods Twen ty-eight surgical infants who had indirect calorimetry measurements while in th e Neonatal Intensive Care Unit between August 2000 and January 2002 were studied . Serum CRP concentrations, mean energy expenditure (MEE), respiratory quotient (RQ), length of hospital stay (LOS), and caloric intake (I) at the time of indir ect calorimetry were recorded. Data were analyzed using the Pearson product-mom ent correlation. Results Peak serum CRP was significantly correlated to LOS in a ll patients (r = 0.79, P < .0001). When net caloric balance (I-MEE) did not e xceed 5 kcal/kg/d (n = 9), peak serum CRP was correlated positively with RQ (r = 0.66, P = .05). When I-MEE exceeded 5 kcal/kg/d (n = 19), the positive corre lation of serum CRP with RQ was diminished (r = 0.23, P = . 33). Conclusions CR P-measured injury severity is a major determinant of clinical outcome in surgic al infants. In addition, overfeeding causes additional RQ elevation. 展开更多
关键词 外科手术 C反应蛋白 热量摄入 重症监护 重危 代谢反应 热量消耗 呼吸商 积差相关 皮尔逊
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