期刊文献+
共找到3篇文章
< 1 >
每页显示 20 50 100
肝内CD4^+淋巴细胞增高与慢性丙型肝炎病人的肝组织损伤
1
作者 杨光 杨黎红 +4 位作者 Sylvia Benzakcn alain Doglio alain bernard Patrick Rampal Albert Tran 《实用肝脏病杂志》 CAS 1999年第1期9-11,共3页
目的 该实验旨在研究慢性丙型肝炎病人周围血和肝内淋巴细胞各亚群变化与丙型肝炎病毒血症、肝脏组织病变活动指数等之间的关系。方法 采用流式细胞仪三色荧光标记单克隆抗体技术对慢性丙型肝炎病人和正常对照的周围血和肝内淋巴细胞各... 目的 该实验旨在研究慢性丙型肝炎病人周围血和肝内淋巴细胞各亚群变化与丙型肝炎病毒血症、肝脏组织病变活动指数等之间的关系。方法 采用流式细胞仪三色荧光标记单克隆抗体技术对慢性丙型肝炎病人和正常对照的周围血和肝内淋巴细胞各亚群进行了测定,同时应用逆转录—多聚酶链反应技术对丙型肝炎病毒血清浓度进行检测并进行了肝组织活检确定肝脏组织病变活动程度。结果 发现慢性丙型肝炎病人肝内CD4^+辅助淋巴细胞比例数显著高于正常对照(20.7±7.3%对10.2±4.6%,p=0.027),并与肝脏组织病变活动指数(Knodell score)呈显著正相关(r=0.48,p=0.004)。周围血淋巴细胞和肝内淋巴细胞亚群堤活性变化有很大不同,但该实验未发现周围血淋巴细胞与病变程度有任何相关。结论 提示机体的免疫反应特别是肝内的区域免疫反应的确在引起肝脏组织细胞损伤的过程中起重要作用,活性CD4^+辅助淋巴细胞可能通过正性调节CD8^+细胞毒性淋巴细胞在肝内造成肝脏组织细胞损伤。 展开更多
关键词 慢性丙型肝炎 淋巴细胞 流式细胞仪 Knodell指数
全文增补中
A Direct Toolpath Constructive Design Method for Controllable Porous Structure Configuration with a TSP-based Sequence Planning Determination 被引量:1
2
作者 Zhiping Wang Yicha Zhang +4 位作者 Donghua Dai Dongdong Gu Chaoyue Chen Di Wang alain bernard 《Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers)》 2023年第1期34-46,共13页
The inherent capabilities of additive manufacturing(AM)to fabricate porous lattice structures with controllable structural and functional properties have raised interest in the design methods for the production of ext... The inherent capabilities of additive manufacturing(AM)to fabricate porous lattice structures with controllable structural and functional properties have raised interest in the design methods for the production of extremely in-tricate internal geometries.Current popular methods of porous lattice structure design still follow the traditional flow,which mainly consists of computer-aided design(CAD)model construction,STereoLithography(STL)model conversion,slicing model acquisition,and toolpath configuration,which causes a loss of accuracy and manufac-turability uncertainty in AM preparation stages.Moreover,toolpath configuration relies on a knowledge-based approach summarized by expert systems.In this process,geometrical construction information is always ignored when a CAD model is created or constructed.To fully use this geometrical information,avoid accuracy loss and ensure qualified manufacturability of porous lattice structures,this paper proposes a novel toolpath-based con-structive design method to directly generate toolpath printing file of parametric and controllable porous lattice structures to facilitate model data exchange during the AM preparation stages.To optimize the laser jumping route between lattice cells,we use a hybrid travelling salesman problem(TSP)solver to determine the laser jumping points on contour scans.Four kinds of laser jumping orders are calculated and compared to select a minimal laser jumping route for sequence planning inside lattice cells.Hence,the proposed method can achieve high-precision lattice printing and avoid computational consumption in model conversion stages from a geomet-rical view.The optical metallographic images show that the shape accuracy of lattice patterns can be guaranteed.The existence of“grain boundaries”brought about by the multi-contour scanning strategy may lead to different mechanical properties. 展开更多
关键词 Design for additive manufacturing Toolpath-based constructive design Porous structure Sequence planning
原文传递
Letter from the Editors-in-Chief
3
作者 Bingheng Lu alain bernard 《Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers)》 2022年第1期49-49,共1页
Chinese Journal of Mechanical Engineering:Additive Manufacturing Frontiers(AMF)has been launched finally!As the very FIRST English peer-reviewed journal of China in the field of additive manufacturing,AMF focuses on s... Chinese Journal of Mechanical Engineering:Additive Manufacturing Frontiers(AMF)has been launched finally!As the very FIRST English peer-reviewed journal of China in the field of additive manufacturing,AMF focuses on serving the scientific innovation,spreading the frontier scientific achievements,and building a high-level comprehensive aca-demic exchange platform. 展开更多
关键词 FRONTIER journal FIRST
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部