Polyploid cells,which contain more than one set of chromosome pairs,are very common in nature.Polyploidy can provide cells with several potential benefits over their diploid counterparts,including an increase in cell ...Polyploid cells,which contain more than one set of chromosome pairs,are very common in nature.Polyploidy can provide cells with several potential benefits over their diploid counterparts,including an increase in cell size,contributing to organ growth and tissue homeostasis,and improving cellular robustness via increased tolerance to genomic stress and apoptotic signals.Here,we focus on why polyploidy in the cell occurs and which stress responses and molecular signals trigger cells to become polyploid.Moreover,we discuss its crucial roles in cell growth and tissue regeneration in the heart,liver,and other tissues.展开更多
基金supported by the Project EVICARE (No.725229)of the European Research Council (ERC)to J.P.G.S.the ZonMw-TAS program (No.116002016)to J.P.G.S./Z.L.+2 种基金the Dutch Ministry of Economic Affairs,Agriculture and Innovation and the Netherlands CardioVascular Research Initiative (CVON)the Dutch Heart Foundation to J.P.G.S.Juntao Fang is supported by a Chinese Scholarship Council (CSC)fellowship program (No.201906210082).AV acknowledges support by the ERCAdG 787171,POLICE.
文摘Polyploid cells,which contain more than one set of chromosome pairs,are very common in nature.Polyploidy can provide cells with several potential benefits over their diploid counterparts,including an increase in cell size,contributing to organ growth and tissue homeostasis,and improving cellular robustness via increased tolerance to genomic stress and apoptotic signals.Here,we focus on why polyploidy in the cell occurs and which stress responses and molecular signals trigger cells to become polyploid.Moreover,we discuss its crucial roles in cell growth and tissue regeneration in the heart,liver,and other tissues.
