Stem cells and tissue engineering have made great strides in plastic surgery.This review of the literature evaluates some current background information and recent advances in our laboratory to bring these areas more ...Stem cells and tissue engineering have made great strides in plastic surgery.This review of the literature evaluates some current background information and recent advances in our laboratory to bring these areas more into the clinical setting.展开更多
Burn wounds result in varying degrees of soft tissue damage that are typically graded clinically.Recently a key participant in neovascularization,the endothelial progenitor cel,has been the subject of intense cardiova...Burn wounds result in varying degrees of soft tissue damage that are typically graded clinically.Recently a key participant in neovascularization,the endothelial progenitor cel,has been the subject of intense cardiovascular research to explore whether it can serve as a biomarker for vascular injury.In this review,we examine the identity of the endothelial progenitor cell as well as the evidence that support its role as a key responder after burn insult.While there is conflicting evidence with regards to the delta of endothelial progenitor cell mobilization and burn severity,it is clear that they play an important role in wound healing.Systematic and controlled studies are needed to clarify this relationship,and whether this population can serve as a biomarker for burn severity.展开更多
文摘Stem cells and tissue engineering have made great strides in plastic surgery.This review of the literature evaluates some current background information and recent advances in our laboratory to bring these areas more into the clinical setting.
基金This work was supported in part by the California Institute for Regenerative Medicine training grant award TG2-012252 from the University of California,Irvine
文摘Burn wounds result in varying degrees of soft tissue damage that are typically graded clinically.Recently a key participant in neovascularization,the endothelial progenitor cel,has been the subject of intense cardiovascular research to explore whether it can serve as a biomarker for vascular injury.In this review,we examine the identity of the endothelial progenitor cell as well as the evidence that support its role as a key responder after burn insult.While there is conflicting evidence with regards to the delta of endothelial progenitor cell mobilization and burn severity,it is clear that they play an important role in wound healing.Systematic and controlled studies are needed to clarify this relationship,and whether this population can serve as a biomarker for burn severity.