The renin angiotensin system (RAS) is emerging as a prominent factor in the development of experimental atherosclerosis. We have previously demonstrated that the RAS is profoundly activated in hypercholesterolemia. Th...The renin angiotensin system (RAS) is emerging as a prominent factor in the development of experimental atherosclerosis. We have previously demonstrated that the RAS is profoundly activated in hypercholesterolemia. This was demonstrated in LDLR-/-mice fed a saturated fat enriched diet and manifested as increased plasma concentrations of angiotensinogen and angiotensin peptides; especially angiotensin Ⅱ (AngⅡ).展开更多
Angiotensin Ⅱ (AngⅡ) is the primary bioactive peptide of the renin angiotensin system that plays a critical role in many cardiovascular diseases.Sub-cutaneous infusion of AngⅡ into mice induces the development of a...Angiotensin Ⅱ (AngⅡ) is the primary bioactive peptide of the renin angiotensin system that plays a critical role in many cardiovascular diseases.Sub-cutaneous infusion of AngⅡ into mice induces the development of abdominal aortic aneurysms (AAAs).Like human AAAs,AngⅡ-induced AAA tissues exhibit progressive changes and considerable heterogeneity.This complex pathology provides an impediment to the quantification of aneurysmal tissue composition by biochemical and immunostaining techniques.Therefore,while the mouse model of AngⅡ-induced AAAs provides a salutary approach to studying the mechanisms of the evolution of AAAs in humans,meaningful interpretation of mechanisms requires consideration of the heterogeneous nature of the diseased tissue.展开更多
文摘The renin angiotensin system (RAS) is emerging as a prominent factor in the development of experimental atherosclerosis. We have previously demonstrated that the RAS is profoundly activated in hypercholesterolemia. This was demonstrated in LDLR-/-mice fed a saturated fat enriched diet and manifested as increased plasma concentrations of angiotensinogen and angiotensin peptides; especially angiotensin Ⅱ (AngⅡ).
基金Project (Nos. HL062846 and HL80100) supported by the National Institutes of Health of the United States of America
文摘Angiotensin Ⅱ (AngⅡ) is the primary bioactive peptide of the renin angiotensin system that plays a critical role in many cardiovascular diseases.Sub-cutaneous infusion of AngⅡ into mice induces the development of abdominal aortic aneurysms (AAAs).Like human AAAs,AngⅡ-induced AAA tissues exhibit progressive changes and considerable heterogeneity.This complex pathology provides an impediment to the quantification of aneurysmal tissue composition by biochemical and immunostaining techniques.Therefore,while the mouse model of AngⅡ-induced AAAs provides a salutary approach to studying the mechanisms of the evolution of AAAs in humans,meaningful interpretation of mechanisms requires consideration of the heterogeneous nature of the diseased tissue.
