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内皮细胞和平滑肌细胞氧化应激时Nrf2/ARE信号通路对抗氧化基因表达的调控:与动脉粥样硬化和先兆子痫的关系 被引量:35
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作者 Giovanni E. Mann Jorg Niehueser-Saran +4 位作者 alan watson Ling Gao Tetsuro Ishii Patricia de Winter Richard C. M. Siow 《生理学报》 CAS CSCD 北大核心 2007年第2期117-127,共11页
动脉粥样硬化、糖尿病、慢性肾功能衰竭和先兆子痫等血管疾病时活性氧(reactive oxygen species,ROS)生成增加,容易导致内皮依赖性血管舒张功能的损害和血管损伤,而细胞可以诱导多种编码Ⅱ相解毒酶和抗氧化蛋白的基因表达,从而减轻ROS... 动脉粥样硬化、糖尿病、慢性肾功能衰竭和先兆子痫等血管疾病时活性氧(reactive oxygen species,ROS)生成增加,容易导致内皮依赖性血管舒张功能的损害和血管损伤,而细胞可以诱导多种编码Ⅱ相解毒酶和抗氧化蛋白的基因表达,从而减轻ROS和亲电子物质介导的细胞损伤。一个被称为抗氧化反应元件(antioxidant response element,ARE)或亲电子反应元件(electrophile response element,EpRE)的顺式转录调控元件,可以介导诸如亚铁血红素加氧酶1、γ-谷氨酰半胱氨酸合成酶、硫氧还蛋白还原酶、谷胱甘肽-S转移酶和NAD(P)H:苯醌氧化还原酶等基因的转录。其他抗氧化酶,如超氧化物歧化酶、过氧化氢酶和非酶清除剂(如谷胱甘肽)等也参与ROS的清除。转录因子NF-E2相关因子2(nuclear factor-erythroid 2-related factor 2, Nrf2)是属于Cap‘n’Collar家族的转录因子,具有碱性亮氨酸拉链(basic region-leucine zipper,bZIP),它在ARE介导的抗氧化基因表达中起重要的作用。在正常情况下,Kelch样环氧氯丙烷相关蛋白-1(Kelch-like ECH-associated protein-1,Keapl)与Nrf2耦联,并与肌动蛋白细胞骨架结合被锚定于胞浆,但是在半胱氨酸残基发生氧化的情况下,Nrf2和Keapl解耦联,进入细胞核并与ARE结合,从而激活多种抗氧化基因和Ⅱ相解毒酶基因的转录。蛋白激酶C、丝裂原活化蛋白激酶和磷脂酰肌醇-3激酶参与Nrf2/ARE信号转导的调控。本文综述了有关Nrf2/ARE信号转导通路在血管稳态和动脉硬化、先兆子痫等疾病情况下内皮及平滑肌细胞对抗持续性氧化应激中起的作用。 展开更多
关键词 转录因子NF-E2相关因子2 抗氧化反应元件 氧化应激 内皮细胞 血管平滑肌细胞 亚铁血红素加氧酶 胱氨酸转运体 一氧化氮合酶 抗氧化基因 Ⅱ相解毒酶 动脉粥样硬化 糖尿病 先兆子痫
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大黄石自然保护地集群空间结构及其对中国的启示
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作者 李鹏 王丹宁 +3 位作者 李晨阳 吴宁远 alan watson 赵敏 《自然资源学报》 CSCD 北大核心 2023年第4期1058-1074,共17页
科学的空间关系和合理的空间结构是保护地治理的基础,美国大黄石生态系统(简称“大黄石”)是多种单元协调共生的保护地集群典范。经过150多年4个时期的建设,大黄石保护地单元空间关系中的边界重叠问题逐步解决,外部相依和内部嵌套相继建... 科学的空间关系和合理的空间结构是保护地治理的基础,美国大黄石生态系统(简称“大黄石”)是多种单元协调共生的保护地集群典范。经过150多年4个时期的建设,大黄石保护地单元空间关系中的边界重叠问题逐步解决,外部相依和内部嵌套相继建立,在更大范围形成土地利用共生圈层和景观尺度的空间相依关系;保护地集群形成了以国家公园为核心、国家森林为主体、其他类型保护地填补空缺的空间结构;“基础—路径—目标”框架可以解释该结构的形成原因,土地权属、政府治理及资源保护利用是保护地集群形成的物质基础、发展路径及建设目标。对中国的启示:空间管控要关注保护地单元的空间关系和保护地集群的空间结构;政府治理要将自上而下、自下而上的方式相结合。 展开更多
关键词 自然保护地集群 空间关系 空间结构 圈层共生模式 大黄石生态系统(大黄石)
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Ocean Sandwioh
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作者 alan watson John Sandford(图) 《小学生时代(大嘴英语)》 2023年第7期30-31,共2页
They say the ocean's filled with food.From sea to shining sea.There's something called a jellyfish,How tasty can that be?Before I get my knife and bread,Before I get my dish,Can anybody help me find The peanut... They say the ocean's filled with food.From sea to shining sea.There's something called a jellyfish,How tasty can that be?Before I get my knife and bread,Before I get my dish,Can anybody help me find The peanut-butter-fish? 展开更多
关键词 OCEAN FILLED SOMETHING
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美国荒野风景河流的空间分布特征及其对中国的启示 被引量:6
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作者 李鹏 赵敏 +2 位作者 艾伦·沃森 杨鹏 余丹 《地理研究》 CSSCI CSCD 北大核心 2020年第1期166-185,共20页
美国荒野风景河流体系是全球最早建立的河流保护地类型。经过50年发展,其完善的体系呈现出一定空间分布特征。将线状国家荒野风景河流(NWSR)抽象为点状单元,对208个NWSR单元进行空间计算,并与自然生态和社会经济等因素进行叠加分析。结... 美国荒野风景河流体系是全球最早建立的河流保护地类型。经过50年发展,其完善的体系呈现出一定空间分布特征。将线状国家荒野风景河流(NWSR)抽象为点状单元,对208个NWSR单元进行空间计算,并与自然生态和社会经济等因素进行叠加分析。结果表明,美国已有40个州分布NWSR,其中以俄勒冈等3个州的数量分布最多,且集中分布于特定的区域:西部的太平洋海岸、落基山脉和山间高地3个自然地理区;极地、温湿润、干旱3个Ⅰ级生态区;太平洋西北部、加利福尼亚、阿拉斯加及五大湖4个流域。NWSR线密度与州域的人口密度、经济水平相关性不强,但与大坝建设密切相关。荒野思想影响了法案制定,法案指导了遴选标准,遴选标准又进一步影响了NWSR的空间分布。研究对中国的借鉴意义在于:应当明确保护地指导思想、关注价值突出区域、确定合适遴选标准、重视保护地系统规划等。 展开更多
关键词 荒野风景河流体系 河流保护地 空间分布规律 河流线密度 核密度
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State of art control of dioxins/unintentional POPs in the secondary copper industry: A review to assist policy making with the implementation of the Stockholm Convention 被引量:2
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作者 Guanglong Wu Roland Weber +3 位作者 Yong Ren Zheng Peng alan watson Jiahong Xie 《Emerging Contaminants》 2020年第1期235-249,共15页
Article 5 of the Stockholm Convention requires that each Party shall take measures to reduce the releases from anthropogenic sources of unintentional persistent organic pollutants(UPOPs),with the goal of their continu... Article 5 of the Stockholm Convention requires that each Party shall take measures to reduce the releases from anthropogenic sources of unintentional persistent organic pollutants(UPOPs),with the goal of their continuing minimization and,where feasible,their ultimate elimination.A major source of polychlorinated dibenzo-p-dioxins and dibenzofurans(PCDD/Fs)and other unintentional POPs releases,both in China and worldwide,is the metal industry in particular secondary metal industries such as copper smelting.More than 50%of the global secondary copper production is now in China and high levels of PCDD/Fs are released from these operations with the national inventory of China reporting a total of 1133.8 g toxic equivalents(TEQ)yr1.Consequently the Global Environment Facility(GEF)is supporting the project‘UPOPs Reduction through best available techniques and best environmental practices(BAT/BEP)in the secondary copper production sector’in China compromising>50%of the global secondary copper production.As part of this project,information on relevant UPOPs from the metal industry have been reviewed and is presented here.This information should also be useful for other(developing)countries for controlling UPOPs releases from metal industries.This review and the information it contains provides a robust resource for policy makers,the industry and researchers to improve secondary copper production to BAT/BEP standards in relation to the reduction of PCDD/Fs and other UPOPs release.The contents include the details required to assist the understanding of the formation of chlorinated UPOPs along with their brominated and brominated-chlorinated analogues.It reviews the international sources of information on BAT/BEP,including the integrated approach considered in the European BAT Reference document,and shows how this can be used to achieve an overall reduction of pollutant releases from the industry.The current national standards of PCDD/F limits to air,water and solid residues have been compiled and are also included.Challenges which need to be addressed,such as the current international lack to consider brominated and mixed bromo-chloro PXDD/Fs which might be more environmentally significant than PCDD/Fs in some facilities e are also discussed.The study includes a brief description of the steps China has taken to change the national regulatory framework and to improve the sustainability of its secondary metal industry.The Stockholm Convention BAT/BEP guidelines recommend consideration of integrated pollution prevention and control and sustainable production as general principles which parties may incorporate when applying the BAT/BEP guidelines and guidance.This holistic approach is considered in the current project and in the improvement of the pilot facilities and will also be considered in the replication of experiences in other facilities.Using this approach ensures the implementation of the Stockholm Convention can contribute to integrated pollution prevention and control,the development of a circular economy and consequently to genuinely sustainable development thus contributing to different sustainable development goals(SDGs).It is hoped this approach will be adopted in other developing and transition economies and thus help to achieve improvements of the secondary metal industry globally. 展开更多
关键词 BAT/BEP Emission control PCDD/PCDF PBDD/PBDF Regulatory limits Circular economy Stockholm convention
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The role of herbivores in the grassland carbon budget for Three-Rivers Headwaters region,Qinghai-Tibetan Plateau,China 被引量:1
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作者 Junbang Wang Xinquan Zhao +7 位作者 Xihuang Ouyang Liang Zhao Wenying Wang Chan Zuo Zhenhua Zhang Huakun Zhou alan watson Yingnian Li 《Grassland Research》 2022年第3期207-219,共13页
Background:An accurate assessment of the carbon budget is a crucial part of projecting future climate change and its impact on ecosystems.Grasslands foster multiple ecological functions including support for wild anim... Background:An accurate assessment of the carbon budget is a crucial part of projecting future climate change and its impact on ecosystems.Grasslands foster multiple ecological functions including support for wild animals and livestocks.Herbivores intake forage biomass carbon,then digest and metabolize,and finally retain some carbon.The carbon processes have not been well quantified,resulting in uncertainties in the estimation of regional carbon budgets for grassland ecosystems.Methods:An animal metabolic carbon flux model was developed for herbivores in the Three-Rivers Headwaters region of China.The forage intake and metabolic carbon rates were estimated through metabolic body weight and daily digested measures for the main herbivore species.Results:The carbon intake was 5.52 Tg C year−1(45%)from partial aboveground biomass(12.2 Tg C year−1),in which 39.31%was released into the atmosphere by respiration CO_(2),43.77%was returned to the ecosystem as feces and urine,and 16.96%was retained in herbivores for population regeneration or for human well-being.Conclusions:This study,as the first research on this topic,quantified the carbon flux of herbivores and found livestock accounts for a major part of consumed carbon on grasslands,which is important for understanding regional carbon budgets to mitigate and adapt to climate change over grasslands worldwide. 展开更多
关键词 aboveground biomass alpine grassland carbon budget HERBIVORES LIVESTOCK METABOLISM
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