Pneumonia is an inflammatory condition of the lung with symptoms that include productive dry cough,fever,chest pain,and difficulty breathing,and it is usually caused by viruses and bacteria,but also other microorganis...Pneumonia is an inflammatory condition of the lung with symptoms that include productive dry cough,fever,chest pain,and difficulty breathing,and it is usually caused by viruses and bacteria,but also other microorganisms(such as fungi and parasites).Community-acquired pneumonia(CAP)is a major cause of infectious diseases,hospitalization,and mortality,especially in the elderly population.展开更多
Progressive osseous heteroplasia(POH)is an ultra-rare autosomal dominant disabling disorder characterized by heterotopic ossification(HO).It is caused by heterozygous inactivating mutations in the GNAS(guanine nucleot...Progressive osseous heteroplasia(POH)is an ultra-rare autosomal dominant disabling disorder characterized by heterotopic ossification(HO).It is caused by heterozygous inactivating mutations in the GNAS(guanine nucleotide-binding protein alpha-stimulating activity polypeptide)gene.However,the molecular mechanisms underlying HO remain poorly understood.As a treatment for POH is not yet available,the identification of the mechanisms driving POH in affected tissues using gene expression may be of great help to underestand the molecular basis of POH and develop new therapeutic approaches.展开更多
基金sponsored by Pfizer.It also received support from Instituto de Salud Carlos III ([ISCIII]TRINEO:No.PI22/00162,DIAVIR:No.DTS19/00049,Resvi-Omics:No.Pl19/01039 (to A.S.)Res Vinext:No.Pl16/01569+7 种基金Enterogen:No.PI19/01090 (to F.M.-T).cofinanciados FEDER,GAIN:Grupos con Potential de Crecimiento No.IN607B 2020/08Grupos de Referencia Competitiva No.IN607A 2023/02 (to A.S.)ACIS:BI-BACVIR No.PRIS-3 (to A.S.),Covid Phy No.SA 304C (to A.S.)consorcio Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias No.CB21/06/00103 (to F.M.-T.)GEN-COVID No.IN845D2020/23 (to F.M.-T.)Grupos de Referencia Competitiva No.IIN607A2021/05 (to F.M.-T).
文摘Pneumonia is an inflammatory condition of the lung with symptoms that include productive dry cough,fever,chest pain,and difficulty breathing,and it is usually caused by viruses and bacteria,but also other microorganisms(such as fungi and parasites).Community-acquired pneumonia(CAP)is a major cause of infectious diseases,hospitalization,and mortality,especially in the elderly population.
文摘Progressive osseous heteroplasia(POH)is an ultra-rare autosomal dominant disabling disorder characterized by heterotopic ossification(HO).It is caused by heterozygous inactivating mutations in the GNAS(guanine nucleotide-binding protein alpha-stimulating activity polypeptide)gene.However,the molecular mechanisms underlying HO remain poorly understood.As a treatment for POH is not yet available,the identification of the mechanisms driving POH in affected tissues using gene expression may be of great help to underestand the molecular basis of POH and develop new therapeutic approaches.
