Objective To assess the effect of altering the timing of hCG administ ration on ongoing pregnancy rates in patients stimu-lated with recombinant FSH (rec-FSH ) and GnRH antagonists for IVF. Design Prospective, randomi...Objective To assess the effect of altering the timing of hCG administ ration on ongoing pregnancy rates in patients stimu-lated with recombinant FSH (rec-FSH ) and GnRH antagonists for IVF. Design Prospective, randomized, controlled trial . Setting Tertiary referral center. Patient(s) Four hundred thirteen patients un dergoing IVF. Intervention(s) Rec-FSH stimulation starting on day 2 of the cycl e combinedwith daily GnRH antagonist starting on day 6 of stimulation. Patients were randomized to receive 10,000 IU of hCG either as soon as at least three fol licles were ≥17 mm on ultrasound (early-hCG group, 208 patients) or 2 days lat er after this criterion was met (late-hCG group, 205 patients). Main outcome me asure(s) Ongoing pregnancy rate. Result(s) Fertilization rates and number and qu ality of embryos transferred did not differ between the two groups. However, a s ignificantly lower ongoing pregnancy rate was present in the late-hCG as compar ed with the early-hCG group (25.0%vs. 35.6%, respectively). Conclusion(s) Pro longation of the follicular phase in patients stimulated with rec-FSH and GnRH antagonists for IVF does not affect oocyte or embryo quality but is associated w ith a significantly lower ongoing pregnancy rate.展开更多
文摘Objective To assess the effect of altering the timing of hCG administ ration on ongoing pregnancy rates in patients stimu-lated with recombinant FSH (rec-FSH ) and GnRH antagonists for IVF. Design Prospective, randomized, controlled trial . Setting Tertiary referral center. Patient(s) Four hundred thirteen patients un dergoing IVF. Intervention(s) Rec-FSH stimulation starting on day 2 of the cycl e combinedwith daily GnRH antagonist starting on day 6 of stimulation. Patients were randomized to receive 10,000 IU of hCG either as soon as at least three fol licles were ≥17 mm on ultrasound (early-hCG group, 208 patients) or 2 days lat er after this criterion was met (late-hCG group, 205 patients). Main outcome me asure(s) Ongoing pregnancy rate. Result(s) Fertilization rates and number and qu ality of embryos transferred did not differ between the two groups. However, a s ignificantly lower ongoing pregnancy rate was present in the late-hCG as compar ed with the early-hCG group (25.0%vs. 35.6%, respectively). Conclusion(s) Pro longation of the follicular phase in patients stimulated with rec-FSH and GnRH antagonists for IVF does not affect oocyte or embryo quality but is associated w ith a significantly lower ongoing pregnancy rate.
