单侧颞叶皮层梗塞对大鼠空间认知加工过程的影响

采用立体定向光化学诱导脑梗塞技术选择性地导致大鼠左侧颞叶皮层梗塞，以探讨颞叶在空间认知加工中的作用。实验观察到，单侧颞叶梗塞大鼠的Ｍｏｒｒｉｓ迷宫学习成绩低于对照组，其搜索目标的反应时和行程都显著延长，搜索策略亦有明显变化。

丹参改善大鼠颞叶梗死后空间认知加工障碍的研究

目的探讨丹参对大鼠单侧颓叶梗死后空间认知加工能力的改善作用。方法采用立体定向光化学诱导脑梗死技术选择性地导致大鼠左侧颞对皮层梗死，术前30min及术后第3天分别给丹参组大鼠按体重腹腔注射丹参10g／kg，行为实验装置由Morris水迷宫及图像自动监视系统（morrismazeexperimentalassistantsystem，MMEAS）组成。结果丹参组大鼠在Morris迷宫中搜索目标的反应时和行程显著缩短，且较多地使用了正常的认知策略，其由随机式过渡到趋向和直线式策略的进程也与正常对照组无明显差异。结论丹参可明显改善大鼠单侧颞叶梗死后的空间认知加工障碍。本研究在丹参治疗脑梗死、预防痴呆发生方面进行了有益的探索。

Effect of Batroxobin on Expression of Neural Cell Adhesion Molecule in Temporal Infarction Rats and Spatial Learning and Memory Disorder

The effect of Batroxobin expression of neural cell adhesion molecule (NCAM) in left temporal ischemic rats with spatial memory disorder was investigated by means of Morri's water maze and immunohistochemical methods. The results showed that the mean reaction time and distance of temporal ischemic rats for searching a goal were significantly longer than those of sham-operated rats and at the same time NCAM expression of left temporal ischemic region was significantly increased. However, the mean reaction time and distance of Batroxobin-treated rats were shorter and they used normal strategies more often and earlier than those of ischemic rats. The number of NCAM immune reactive cells of Batroxobin-treated rats was more than that of ischemic group. In conclusion, Batroxobin can improve spatial memory disorder of temporal ischemic rats and the regulation of the expression of NCAM is probably related to the neuroprotective mechanism.