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A Comparison of Airborne Formaldehyde Field Measurements Collected in an Anatomic Pathology Laboratory
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作者 Maria Teresa Piccardo Massimo Cipolla +2 位作者 alberto izzotti Paola Canepa Vincenzo Fontana 《Journal of Environmental Protection》 2024年第8期827-841,共15页
Environmental monitoring of airborne formaldehyde (FA) using sensitive methodologies is fundamental to prevent health risks. The objective of this study was to compare three different FA monitoring methods during the ... Environmental monitoring of airborne formaldehyde (FA) using sensitive methodologies is fundamental to prevent health risks. The objective of this study was to compare three different FA monitoring methods during the daily activities of an anatomic pathology laboratory. Daily eight-hour measurements deriving from Radiello® passive diffusive samplers (PDS), NEMo XT continuous optical sensor (COS), and multi-gas 1512 photoacoustic monitor (MPM) were simultaneously compared over a period of 14 working days. Given the different daily distributions of the measurements performed by the three devices, all measurements were time-aligned for comparison purposes. The 95% limit of agreement (LOA) method was applied to estimate the degree of concordance of each device with respect to the others. Formaldehyde arithmetic mean measured using PDS was 32.6 ± 10.4 ppb (range: 19.8 - 62.7). The simultaneous measures performed by COS and MPM were respectively 42.4 ± 44.8 ppb (range: 7.0 - 175.0) and 189.0 ± 163.7 ppb (range: 40.0 - 2895.4). The MPM geometric mean (171.3 ppb) was approximately five times higher than those derived from COS (32.3 ppb) and PDS (31.4 ppb). The results of the LOA method applied to log-transformed FA data showed the same systematic discrepancies between MPM and the other two devices. A good agreement between PDS and COS could lead to a tailored approach according to the individual specificity of these techniques. This tool may be useful for accurately assessing the risk of FA exposure among healthcare workers. However, the limited specificity of the MPM does not support its use as a monitoring method for FA in the workplace. 展开更多
关键词 Occupational Exposure Occupational Health Formaldehyde Monitoring Devices Indoor Air Quality
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人小梁网的氧化DNA损害——与原发性开角青光眼患者的临床相关性 被引量:12
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作者 Sergio Claudio Sacca Antonio Pascotto +4 位作者 Paola Camicione Paolo Capris alberto izzotti 林旭初(译) 惠延年(校) 《美国医学会眼科杂志(中文版)》 2005年第4期208-213,共6页
目的:评价氧化的分子损害的强度及其临床相关性:视野(VF)损害、眼压、年龄和病程长短。 方法:从17例行标准滤过手术的青光眼患者收集的人小梁网标本中提取DNA。与21只角膜移植收集的健康眼标本作对照。氧化DNA损害由测定8-羟基-2... 目的:评价氧化的分子损害的强度及其临床相关性:视野(VF)损害、眼压、年龄和病程长短。 方法:从17例行标准滤过手术的青光眼患者收集的人小梁网标本中提取DNA。与21只角膜移植收集的健康眼标本作对照。氧化DNA损害由测定8-羟基-2’-脱氧鸟苷(8-OH-dG)水平来估价。所有患者术前均经Humphrey 30-2视野检查和日间眼压测量。 结果:在青光眼患者和对照组中,DNA氧化损害的均数±标准差分别为8.51±5.44和1.75±1.80 8-OH-dG个分子/10。正常核苷酸。在人小梁网DNA氧化损害、视野损害和眼压之间发现了统计学上显著的相关性。没有发现其他统计学上的显著相关性。 结论:氧化应激在原发性开角青光眼代表着一个重要的致病步骤。因为它诱发了人小梁网的变性,有助于眼压升高。由此启动了青光眼的发病级联过程。 展开更多
关键词 原发性开角青光眼 DNA损害 青光眼患者 氧化损害 临床相关性 小梁网 眼压测量 病程长短 滤过手术 角膜移植
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