In this review,we will discuss the use of two optical biopsy modalities in inflammatory bowel disease(IBD).The two techniques reviewed here are confocal laser endomicroscopy and endocytoscopy.We will describe the tech...In this review,we will discuss the use of two optical biopsy modalities in inflammatory bowel disease(IBD).The two techniques reviewed here are confocal laser endomicroscopy and endocytoscopy.We will describe the technical performance of the procedure,discuss the clinical indications for optical biopsy in IBD,and highlight active research areas with respect to the pathogenesis of IBD.Clinical indications for optical biopsies in IBD include assessment of mucosal inflammation,dysplasia detection and evaluation of cell shedding for disease relapse.Research application in the area of barrier dysfunction will also be discussed.展开更多
基金Supported by Dr.Julia Liu is a recipient of the Canadian Institute of Health Research New Investigator Salary Award,and funding support from the Canadian Association of Gastroenterology and Crohn’s and Colitis Foundation of CanadaDr.Aldona Dlugosz is a recipient of the Postdoctoral Fellowship from Stockholm County Council and funding support from the Karolinska Institute FundsDr.Helmut Neumann is a recipient of the 2013 American Society for Gastrointestinal Endoscopy Cook Medical Don Wilson Award
文摘In this review,we will discuss the use of two optical biopsy modalities in inflammatory bowel disease(IBD).The two techniques reviewed here are confocal laser endomicroscopy and endocytoscopy.We will describe the technical performance of the procedure,discuss the clinical indications for optical biopsy in IBD,and highlight active research areas with respect to the pathogenesis of IBD.Clinical indications for optical biopsies in IBD include assessment of mucosal inflammation,dysplasia detection and evaluation of cell shedding for disease relapse.Research application in the area of barrier dysfunction will also be discussed.
