We describe a 72-year-old woman with a 13-year history of a lichenoid dermatitis, who developed multiple, papular keratoacanthoma (KA)-like lesions and few crater-like nodules on the extremities over a period of 6 mon...We describe a 72-year-old woman with a 13-year history of a lichenoid dermatitis, who developed multiple, papular keratoacanthoma (KA)-like lesions and few crater-like nodules on the extremities over a period of 6 months before our observation. Her medical history also recorded multiple myeloma diagnosed a few years before. The long-standing dermatosis was diagnosed, clinically, as keratosis lichenoides chronica (KLC), although, histologically, a lichenoid tissue reaction pattern was not evident. On the other hand, histology from papular and nodular lesions of recent onset was consistent with a possible early phase of KA and spinocellular carcinoma, respectively. Oral acitretin induced regression of KA-like lesions and improvement of KLC but had no effects on crater-like nodules, which required surgical excision, KLC is a chronic disorder of keratinization characterized by lichenoid hyperkeratotic papules arranged in a linear pattern, erythematosquamous plaques and seborrhoea-like dermatitis. We emphasize in our case the association between KLC and multiple possible KAs, never previously reported, and speculate that these two rare conditions may represent here a ’ continuum’ from a pathogenetic point of view.展开更多
We describe a male patient with rosacea who had a 2-year history of persistent bilateral oedema of the eyelids, leading to an elephantoid condition with blepharoptosis.An upper eyelid blepharoplasty was performed, but...We describe a male patient with rosacea who had a 2-year history of persistent bilateral oedema of the eyelids, leading to an elephantoid condition with blepharoptosis.An upper eyelid blepharoplasty was performed, but swelling progressively recurred over a few months.Based on the case history, clinical appearance and histological findings, rosaceous lymphoedema was considered to be the diagnosis.The latter is a bilateral, solid oedema of the mid-third of the face, regarded as a rare complication of rosacea.It is thought to occur as a result of chronic inflammation and lymphatic stasis, but its exact aethiopathogenesis remains elusive.Predominant eyelid involvement, causing severe visual impairment as in our patient, is unique.展开更多
Anetoderma is a rare cutaneous disease characterized by a loss of normal elast ic tissue that is presented clinically as localized areas of wrinkled or flaccid skin. This form may be associated with several immunologi...Anetoderma is a rare cutaneous disease characterized by a loss of normal elast ic tissue that is presented clinically as localized areas of wrinkled or flaccid skin. This form may be associated with several immunological abnormalities, mos t notably lupus erythematosus and antiphospholipid antibodies with or without cl inical manifestations of the antiphospholipid syndrome. A retrospective study wa s conducted with the aim of summarizing the clinical characteristics, course and laboratory findings in three women with anetoderma-associated lupus erythemato sus panniculitis, an unusual variant of cutaneous lupus erythematosus. The 3 pat ients (of the 12 patients with lupus erythematosus panniculitis seen by us since 1990) were all at a young age at onset of panniculitis (median, 22 years). None of the patients developed severe systemic involvement up to 9 years (median, 5 years) from onset of the disease. The most noteworthy laboratory finding was the presence of antiphospholipid antibodies. Anetodermic lupus erythematosus pannic ulitis may be regarded as an uncommon variant of cutaneous lupus erythematosus m ainly affecting young females and showing a favourable clinical course, although the patients should be followed and screened for the emergence of antiphospholi pid syndrome. Antiphospholipid antibodies could play a role in the elastolytic p rocess, leading to anetoderma.展开更多
文摘We describe a 72-year-old woman with a 13-year history of a lichenoid dermatitis, who developed multiple, papular keratoacanthoma (KA)-like lesions and few crater-like nodules on the extremities over a period of 6 months before our observation. Her medical history also recorded multiple myeloma diagnosed a few years before. The long-standing dermatosis was diagnosed, clinically, as keratosis lichenoides chronica (KLC), although, histologically, a lichenoid tissue reaction pattern was not evident. On the other hand, histology from papular and nodular lesions of recent onset was consistent with a possible early phase of KA and spinocellular carcinoma, respectively. Oral acitretin induced regression of KA-like lesions and improvement of KLC but had no effects on crater-like nodules, which required surgical excision, KLC is a chronic disorder of keratinization characterized by lichenoid hyperkeratotic papules arranged in a linear pattern, erythematosquamous plaques and seborrhoea-like dermatitis. We emphasize in our case the association between KLC and multiple possible KAs, never previously reported, and speculate that these two rare conditions may represent here a ’ continuum’ from a pathogenetic point of view.
文摘We describe a male patient with rosacea who had a 2-year history of persistent bilateral oedema of the eyelids, leading to an elephantoid condition with blepharoptosis.An upper eyelid blepharoplasty was performed, but swelling progressively recurred over a few months.Based on the case history, clinical appearance and histological findings, rosaceous lymphoedema was considered to be the diagnosis.The latter is a bilateral, solid oedema of the mid-third of the face, regarded as a rare complication of rosacea.It is thought to occur as a result of chronic inflammation and lymphatic stasis, but its exact aethiopathogenesis remains elusive.Predominant eyelid involvement, causing severe visual impairment as in our patient, is unique.
文摘Anetoderma is a rare cutaneous disease characterized by a loss of normal elast ic tissue that is presented clinically as localized areas of wrinkled or flaccid skin. This form may be associated with several immunological abnormalities, mos t notably lupus erythematosus and antiphospholipid antibodies with or without cl inical manifestations of the antiphospholipid syndrome. A retrospective study wa s conducted with the aim of summarizing the clinical characteristics, course and laboratory findings in three women with anetoderma-associated lupus erythemato sus panniculitis, an unusual variant of cutaneous lupus erythematosus. The 3 pat ients (of the 12 patients with lupus erythematosus panniculitis seen by us since 1990) were all at a young age at onset of panniculitis (median, 22 years). None of the patients developed severe systemic involvement up to 9 years (median, 5 years) from onset of the disease. The most noteworthy laboratory finding was the presence of antiphospholipid antibodies. Anetodermic lupus erythematosus pannic ulitis may be regarded as an uncommon variant of cutaneous lupus erythematosus m ainly affecting young females and showing a favourable clinical course, although the patients should be followed and screened for the emergence of antiphospholi pid syndrome. Antiphospholipid antibodies could play a role in the elastolytic p rocess, leading to anetoderma.
