We found that rotavirus-infected cells produce paracrine signals that manifested as intercellular calcium waves(ICWs),observed in cell lines and human intestinal enteroids.Rotavirus ICWs were caused by the release of ...We found that rotavirus-infected cells produce paracrine signals that manifested as intercellular calcium waves(ICWs),observed in cell lines and human intestinal enteroids.Rotavirus ICWs were caused by the release of extracellular adenosine 5'-diphosphate(ADP)that activated P2Y1 purinergic receptors on neighboring cells.Thus,rotavirus exploited paracrine purinergic signaling to generate ICWs that amplified the dysregulation of host cells and altered gastrointestinal physiology to cause diarrhea.展开更多
文摘We found that rotavirus-infected cells produce paracrine signals that manifested as intercellular calcium waves(ICWs),observed in cell lines and human intestinal enteroids.Rotavirus ICWs were caused by the release of extracellular adenosine 5'-diphosphate(ADP)that activated P2Y1 purinergic receptors on neighboring cells.Thus,rotavirus exploited paracrine purinergic signaling to generate ICWs that amplified the dysregulation of host cells and altered gastrointestinal physiology to cause diarrhea.