Background:Nicotine administration can generate severe oxidative stress and lipid peroxidation.Royal jelly,with its antioxidant properties,acts as a scavenger of reactive oxygen species.This study describes the apithe...Background:Nicotine administration can generate severe oxidative stress and lipid peroxidation.Royal jelly,with its antioxidant properties,acts as a scavenger of reactive oxygen species.This study describes the apitherapy effects of royal jelly on testicular damage following nicotine administration.Methods:Forty-eight male BALB/c mice were divided into 8 groups(n=6):saline,3 different doses of royal jelly(100,150,and 200 mg/kg body weight(BW)per day),nicotine(1.5 mg/kg),and 3 different groups of Nic+Roy(1.5 mg/kg of Nic+100,150,and 200 mg/kg BW per day of royal jelly).Nicotine was administrated intraperitoneally,and royal jelly was prescribed orally for 10 consecutive days.Serum levels of hormones(testosterone,luteinizing hormone,and follicle-stimulating hormone),total antioxidant capacity,nitric oxide(NO)status,malondialdehyde levels,sperm DNA fragmentation,sperm parameters,histopathological changes(H&E staining),immunohistochemistry against apoptotic proteins,and gene expression of Bcl-2,p53,Caspase-3,and Nrf2(real-time PCR)were assessed to evaluate the molecular and histological changes.Results:Hormone levels,sperm parameters,and status of antioxidants were decreased significantly(p<.05)following nicotine administration.Moreover,royal jelly treatment normalized hormonal and antioxidant characteristics,decreased apoptotic gene expression,increased Nfr2 gene expression,and restored histopathological alteration to the physiological status significantly(p<.05).Conclusion:Royal jelly upregulates the antioxidant status,inhibits the mitochondrialdependent apoptosis pathway,and increases the rate of proliferation.This therapeutic agent effectively protected the testis against nicotine-associated damages by antioxidant and anti-apoptotic effects.展开更多
Seismic permanent displacement of the soil walls plays an important role in design of these structures. Due to the increase in growth of urban areas and the limitations in use of flat grounds, many structures are buil...Seismic permanent displacement of the soil walls plays an important role in design of these structures. Due to the increase in growth of urban areas and the limitations in use of flat grounds, many structures are built near slopes and retaining walls. During earthquakes, these structures can apply an additional surcharge on the wall. The intensity and location of the surcharge is of considerable importance on the seismic displacements of the soil wall. In this study, by using the limit analysis and upper bound theorem, seismic permanent displacement of the soil wall under surcharge has been analyzed. Thus, a formulation is presented for calculating the yield acceleration and seismic displacement for different surcharge conditions. The effect of seismic acceleration, surcharge intensity, its location and soil properties is investigated. A parameter called the ＂displacement coefficient＂ is proposed, and is a potential modification for Newmark’s sliding-block method.展开更多
In spite of the good performance of the steel plate shear wall(SPSW)in recent earthquakes and experimental studies,the need for huge columns to surround the infill plate is a major shortcoming of the system.This short...In spite of the good performance of the steel plate shear wall(SPSW)in recent earthquakes and experimental studies,the need for huge columns to surround the infill plate is a major shortcoming of the system.This shortcoming can be resolved by using semi-supported SPSW.The semi-supported SPSW has secondary columns that prevent the transfer of stress from the infill plate to the main columns.In spite of extensive experimental and numerical investigations on SPSWs,there are many ambiguities regarding the behavior of the semi-supported SPSW.Although stress in the columns is reduced,incomplete diagonal tension field action is formed in the infill plate that creates new problems.In this paper,a new type of semi-supported SPSW is presented in which the steel plate and the secondary columns are angled.The creation of the angle of the plate and the secondary column makes it possible to use the full capacity of the steel plate as well as the capacity of the secondary columns.Numerical results showed that the wall with a 60°angle has a favorable performance relative to the semi-supported wall.Moreover,with the 60°angle,stiffness,strength and energy absorption is increased.The angle of the secondary columns has little effect on the non-elastic stiffness.Nevertheless,using a wall with an angle of more than 90°can neutralize the wall’s behavior relative to conventional walls.Therefore,the wall with a 60°angle as an optimal angle is recommended.展开更多
基金funded by Kermanshah University of Medical Sciences(grant no.96067)。
文摘Background:Nicotine administration can generate severe oxidative stress and lipid peroxidation.Royal jelly,with its antioxidant properties,acts as a scavenger of reactive oxygen species.This study describes the apitherapy effects of royal jelly on testicular damage following nicotine administration.Methods:Forty-eight male BALB/c mice were divided into 8 groups(n=6):saline,3 different doses of royal jelly(100,150,and 200 mg/kg body weight(BW)per day),nicotine(1.5 mg/kg),and 3 different groups of Nic+Roy(1.5 mg/kg of Nic+100,150,and 200 mg/kg BW per day of royal jelly).Nicotine was administrated intraperitoneally,and royal jelly was prescribed orally for 10 consecutive days.Serum levels of hormones(testosterone,luteinizing hormone,and follicle-stimulating hormone),total antioxidant capacity,nitric oxide(NO)status,malondialdehyde levels,sperm DNA fragmentation,sperm parameters,histopathological changes(H&E staining),immunohistochemistry against apoptotic proteins,and gene expression of Bcl-2,p53,Caspase-3,and Nrf2(real-time PCR)were assessed to evaluate the molecular and histological changes.Results:Hormone levels,sperm parameters,and status of antioxidants were decreased significantly(p<.05)following nicotine administration.Moreover,royal jelly treatment normalized hormonal and antioxidant characteristics,decreased apoptotic gene expression,increased Nfr2 gene expression,and restored histopathological alteration to the physiological status significantly(p<.05).Conclusion:Royal jelly upregulates the antioxidant status,inhibits the mitochondrialdependent apoptosis pathway,and increases the rate of proliferation.This therapeutic agent effectively protected the testis against nicotine-associated damages by antioxidant and anti-apoptotic effects.
文摘Seismic permanent displacement of the soil walls plays an important role in design of these structures. Due to the increase in growth of urban areas and the limitations in use of flat grounds, many structures are built near slopes and retaining walls. During earthquakes, these structures can apply an additional surcharge on the wall. The intensity and location of the surcharge is of considerable importance on the seismic displacements of the soil wall. In this study, by using the limit analysis and upper bound theorem, seismic permanent displacement of the soil wall under surcharge has been analyzed. Thus, a formulation is presented for calculating the yield acceleration and seismic displacement for different surcharge conditions. The effect of seismic acceleration, surcharge intensity, its location and soil properties is investigated. A parameter called the ＂displacement coefficient＂ is proposed, and is a potential modification for Newmark’s sliding-block method.
文摘In spite of the good performance of the steel plate shear wall(SPSW)in recent earthquakes and experimental studies,the need for huge columns to surround the infill plate is a major shortcoming of the system.This shortcoming can be resolved by using semi-supported SPSW.The semi-supported SPSW has secondary columns that prevent the transfer of stress from the infill plate to the main columns.In spite of extensive experimental and numerical investigations on SPSWs,there are many ambiguities regarding the behavior of the semi-supported SPSW.Although stress in the columns is reduced,incomplete diagonal tension field action is formed in the infill plate that creates new problems.In this paper,a new type of semi-supported SPSW is presented in which the steel plate and the secondary columns are angled.The creation of the angle of the plate and the secondary column makes it possible to use the full capacity of the steel plate as well as the capacity of the secondary columns.Numerical results showed that the wall with a 60°angle has a favorable performance relative to the semi-supported wall.Moreover,with the 60°angle,stiffness,strength and energy absorption is increased.The angle of the secondary columns has little effect on the non-elastic stiffness.Nevertheless,using a wall with an angle of more than 90°can neutralize the wall’s behavior relative to conventional walls.Therefore,the wall with a 60°angle as an optimal angle is recommended.
