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Calcitonin and vitamin D3 have high therapeutic potential for improving diabetic mandibular growth 被引量:1
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作者 Mona A Abbassy Ippei Watari +2 位作者 Ahmed S Bakry Takashi Ono ali h hassan 《International Journal of Oral Science》 SCIE CAS CSCD 2016年第1期39-44,共6页
The goal of this study was to assess the effect of the intermittent combination of an antiresorptive agent (calcitonin) and an anabolic agent (vitamin D3) on treating the detrimental effects of Type 1 diabetes mel... The goal of this study was to assess the effect of the intermittent combination of an antiresorptive agent (calcitonin) and an anabolic agent (vitamin D3) on treating the detrimental effects of Type 1 diabetes mellitus (DM) on mandibular bone formation and growth. Forty 3-week-old male Wistar rats were divided into four groups: the control group (normal rats), the control C+D group (normal rats injected with calcitonin and vitamin D3), the diabetic C+D group (diabetic rats injected with calcitonin and vitamin D3) and the diabetic group (uncontrolled diabetic rats). An experimental DM condition was induced in the male Wistar rats in the diabetic and diabetic C+ D groups using a single dose of 60 mg.kg-1 body weight of streptozotocin. Calcitonin and vitamin D3 were simultaneously injected in the rats of the control C+D and diabetic C+D groups. All rats were killed after 4 weeks, and the right mandibles were evaluated by micro-computed tomography and histomorphometric analysis. Diabetic rats showed a significant deterioration in bone quality and bone formation (diabetic group). By contrast, with the injection of calcitonin and vitamin D3, both bone parameters and bone formation significantly improved (diabetic C+ D group) (P 〈 0.05). These findings suggest that these two hormones might potentially improve various bone properties. 展开更多
关键词 type 1 diabetes mellitus mandibular bone structure mandibular bone formation micro-computed tomography BONE HISTOMORPHOMETRY
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