The first described vancomycin resistant enterococci (VRE) was about twenty years ago. Recently VRE have been reported by many clinics. However endocarditis due to VRE is still a rare entity and there are only a few c...The first described vancomycin resistant enterococci (VRE) was about twenty years ago. Recently VRE have been reported by many clinics. However endocarditis due to VRE is still a rare entity and there are only a few cases reported in the literature. We are reporting a 59-year-old male patient with chronic renal failure who was on hemodialysis. He presented with a sudden onset of fever, tachycardia and respiratory distress. The performed echocardiography revealed vegetations on the mitral and aortic valves. As he was diagnosed to have infective endocarditis the patient was put on ampicillin and gentamicin therapy. He underwent an emergent mitral and aortic valve surgery due to ensued heart failure. While he was still on ampicillin and gentamicin therapy, E. gallinarum, which was resistant to vancomycin (MIC = 8 mg/L), was isolated from the surgical valve specimens and hence his antibiotic regime was switched to teicoplanin (MIC < 0.5 mg/L). 28 days after teicoplanin therapy the patient was discharged with free of symptoms and any complication. This patient is presented as an example for an endocarditis with an unusual type of enterococci.展开更多
The Acıgöl Graben in SW Turkey,ca.50-55 km in length and 11-15 km in width,formed during the Miocene to Quaternary periods.This graben is bounded by active normal faults of MaymundağıFault(MF)to the northwest and...The Acıgöl Graben in SW Turkey,ca.50-55 km in length and 11-15 km in width,formed during the Miocene to Quaternary periods.This graben is bounded by active normal faults of MaymundağıFault(MF)to the northwest and the GemişFault Zone(GFZ)to the southeast that have triggered significant earthquakes,causing considerable damage.This study focuses on the Bozkurt segment of the MF,which caused a damaging earthquake(Mw 6.0)in 2019 and another significant earthquake in 1886 during historical times.A paleoseismological trench survey along the Bozkurt segment revealed at least two faulting events,with the last event producing a vertical displacement of 0.25 m.The Optical Stimulated Luminescence(OSL)dating indicates that the last earthquake occurred 3.13±0.33 ka BP,while the penultimate earthquake occurred 4.0±0.72 ka BP.These dates correspond to a long-term slip rate of approximately 0.36±0.11 mm/a and a mean recurrence interval of 2.08 ka,short-term slip rate 0.78±0.16 mm/a and recurrence interval of 0.96 ka,and compatible with the mean sedimentation rate of 0.26 mm/a,calculated from drill logs in Acıgöl basin-fill.Considering the 6 km length of the Bozkurt segment and its vertical displacement of 0.25 m in the last event,this segment has the potential to generate earthquakes ranging from 5.6 to 5.9 Mw.Long-term slip rates derived from geomorphological data are 0.56 mm/year to the north and 0.64 mm/a to the south of the graben,indicating higher subsidence on the southern margin.These rates are in accordance with the slip rates calculated from the paleoseismological trench survey and sedimentation rate from the drill-log.These indications show that the Bozkurt segment is an active Holocene fault with relatively long recurrence intervals and low-slip rate.Consequently,the paleoseismological studies in combination with geomorphological data are important tool to assess seismic hazards and to define the characteristics of individual fault segments.展开更多
文摘The first described vancomycin resistant enterococci (VRE) was about twenty years ago. Recently VRE have been reported by many clinics. However endocarditis due to VRE is still a rare entity and there are only a few cases reported in the literature. We are reporting a 59-year-old male patient with chronic renal failure who was on hemodialysis. He presented with a sudden onset of fever, tachycardia and respiratory distress. The performed echocardiography revealed vegetations on the mitral and aortic valves. As he was diagnosed to have infective endocarditis the patient was put on ampicillin and gentamicin therapy. He underwent an emergent mitral and aortic valve surgery due to ensued heart failure. While he was still on ampicillin and gentamicin therapy, E. gallinarum, which was resistant to vancomycin (MIC = 8 mg/L), was isolated from the surgical valve specimens and hence his antibiotic regime was switched to teicoplanin (MIC < 0.5 mg/L). 28 days after teicoplanin therapy the patient was discharged with free of symptoms and any complication. This patient is presented as an example for an endocarditis with an unusual type of enterococci.
文摘The Acıgöl Graben in SW Turkey,ca.50-55 km in length and 11-15 km in width,formed during the Miocene to Quaternary periods.This graben is bounded by active normal faults of MaymundağıFault(MF)to the northwest and the GemişFault Zone(GFZ)to the southeast that have triggered significant earthquakes,causing considerable damage.This study focuses on the Bozkurt segment of the MF,which caused a damaging earthquake(Mw 6.0)in 2019 and another significant earthquake in 1886 during historical times.A paleoseismological trench survey along the Bozkurt segment revealed at least two faulting events,with the last event producing a vertical displacement of 0.25 m.The Optical Stimulated Luminescence(OSL)dating indicates that the last earthquake occurred 3.13±0.33 ka BP,while the penultimate earthquake occurred 4.0±0.72 ka BP.These dates correspond to a long-term slip rate of approximately 0.36±0.11 mm/a and a mean recurrence interval of 2.08 ka,short-term slip rate 0.78±0.16 mm/a and recurrence interval of 0.96 ka,and compatible with the mean sedimentation rate of 0.26 mm/a,calculated from drill logs in Acıgöl basin-fill.Considering the 6 km length of the Bozkurt segment and its vertical displacement of 0.25 m in the last event,this segment has the potential to generate earthquakes ranging from 5.6 to 5.9 Mw.Long-term slip rates derived from geomorphological data are 0.56 mm/year to the north and 0.64 mm/a to the south of the graben,indicating higher subsidence on the southern margin.These rates are in accordance with the slip rates calculated from the paleoseismological trench survey and sedimentation rate from the drill-log.These indications show that the Bozkurt segment is an active Holocene fault with relatively long recurrence intervals and low-slip rate.Consequently,the paleoseismological studies in combination with geomorphological data are important tool to assess seismic hazards and to define the characteristics of individual fault segments.
