Objectives:To determine changes in the distribution of uropathogens and their antimicrobial resistance in pediatric patients in a children's hospital from 2005 to 2016.Methods:A cross-sectional analysis of uropath...Objectives:To determine changes in the distribution of uropathogens and their antimicrobial resistance in pediatric patients in a children's hospital from 2005 to 2016.Methods:A cross-sectional analysis of uropathogens and their antimicrobial resistance within inpatient children was performed over the 11-year period,2005 to 2016,in Ali Asghar children's hospital.The rate of antibiotic resistance among patients was evaluated according to demographic data including age,sex,urinary tract abnormities and history of antibiotic consumption.Results:In total,958 female and 349 male positive cultures were analyzed.Escherichia coli(E.coli)(77.6%)was the most common causative agent of urinary tract infection(UTI)in children and Klebsiella pneumoniae(10.4%),Pseudomonas aeruginosa(2.4%),and Enterococcus spp(2.4%)were less frequent isolated bacteria.The resistance rates of E.coli isolates were increased against amikacin,ceftriaxone,ceftazidime,ciprofloxacin,cotrimoxazole and imipenem from 2005 to 2010.However,we observed a decreasing trend for some of antibiotics including amikacin,gentamicin,imipenem,ceftazidime and cotrimoxazole during 2014-2016.The rate of antibiotic resistance was greater in boys than in girls against many antibiotics.The rate of resistance to amikacin,gentamicin,nitrofurantoin and cotrimoxazole in patients aged<1 year was higher than other age groups(p<0.001).A higher antibiotic resistance rate was observed in patients with anatomical abnormality and those who have had a history of antibiotic consumption.Conclusion:The study indicated the significant decrease in E.coli antibiotic resistance in the last 3 years.An effective empirical treatment regime should be based on local epidemiology and antimicrobial susceptibility testing.展开更多
文摘Objectives:To determine changes in the distribution of uropathogens and their antimicrobial resistance in pediatric patients in a children's hospital from 2005 to 2016.Methods:A cross-sectional analysis of uropathogens and their antimicrobial resistance within inpatient children was performed over the 11-year period,2005 to 2016,in Ali Asghar children's hospital.The rate of antibiotic resistance among patients was evaluated according to demographic data including age,sex,urinary tract abnormities and history of antibiotic consumption.Results:In total,958 female and 349 male positive cultures were analyzed.Escherichia coli(E.coli)(77.6%)was the most common causative agent of urinary tract infection(UTI)in children and Klebsiella pneumoniae(10.4%),Pseudomonas aeruginosa(2.4%),and Enterococcus spp(2.4%)were less frequent isolated bacteria.The resistance rates of E.coli isolates were increased against amikacin,ceftriaxone,ceftazidime,ciprofloxacin,cotrimoxazole and imipenem from 2005 to 2010.However,we observed a decreasing trend for some of antibiotics including amikacin,gentamicin,imipenem,ceftazidime and cotrimoxazole during 2014-2016.The rate of antibiotic resistance was greater in boys than in girls against many antibiotics.The rate of resistance to amikacin,gentamicin,nitrofurantoin and cotrimoxazole in patients aged<1 year was higher than other age groups(p<0.001).A higher antibiotic resistance rate was observed in patients with anatomical abnormality and those who have had a history of antibiotic consumption.Conclusion:The study indicated the significant decrease in E.coli antibiotic resistance in the last 3 years.An effective empirical treatment regime should be based on local epidemiology and antimicrobial susceptibility testing.
