A molecular dynamics study to investigate the cavity control of Prefoldin based bio nano actuator is presented in this paper. Prefoldin is a molecular chaperone with a jellyfish-like structure containing six long coil...A molecular dynamics study to investigate the cavity control of Prefoldin based bio nano actuator is presented in this paper. Prefoldin is a molecular chaperone with a jellyfish-like structure containing six long coiled-coil tentacles and a large central cavity. We took the temperature and p H of the medium into account,and analyzed the conformational flexibility of the Prefoldin nano actuator in details. Results show that the prefoldin is a very flexible protein, the conformational state of which appears to depend on the temperature and p H values of the medium. In fact, combining these two control parameters, a suitable environment is provided to capture nano cargoes with specific dimensions. These properties of Prefoldin actuator can be used for drug delivery in the body.展开更多
Cobalt ferrite nanoparticles（CFNPs） were prepared via a reverse micelle method. The CFNPs were subsequently coated with carbon shells by means of thermal chemical vapor deposition（TCVD）. In this process, acetylene...Cobalt ferrite nanoparticles（CFNPs） were prepared via a reverse micelle method. The CFNPs were subsequently coated with carbon shells by means of thermal chemical vapor deposition（TCVD）. In this process, acetylene gas（C2H2） was used as a carbon source and the coating was carried out for 1, 2, or 3 h at 750℃. The Ar/C2H2 ratio was 10：1. Heating during the TCVD process resulted in a NP core size that approached 30 nm; the thickness of the shell was less than 10 nm. The composition, structure, and morphology of the fabricated composites were characterized using X-ray diffraction, simultaneous thermal analysis, transmission electron microscopy, high-resolution transmission electron microscopy, and selected-area diffraction. A vibrating sample magnetometer was used to survey the samples＇ magnetic properties. The deposited carbon shell substantially affected the growth and magnetic properties of the CFNPs. Micro-Raman spectroscopy was used to study the carbon coating and revealed that the deposited carbon comprised graphite, multiwalled carbon nanotubes, and diamond-like carbon. With an increase in coating time, the intensity ratio between the amorphous and ordered peaks in the Raman spectra decreased, which indicated an increase in crystallite size.展开更多
Preparation of iron oxide （α-Fe2O3） nanoparticles was carried out via a sonochemical process. The process parameters sucb as temperature, sonication time and power of ultrasonication play important roles in the siz...Preparation of iron oxide （α-Fe2O3） nanoparticles was carried out via a sonochemical process. The process parameters sucb as temperature, sonication time and power of ultrasonication play important roles in the size and morphology of the final products. The iron oxide nanoparticles were characterized by trans- mission electron microscopy, X-ray powder diffraction, and thermogravimetric and differential thermal analyses. From transmission electron microscopy observations, the size of the iron oxide nanoparticles is estimated to be significantly smaller than 19 nm. X-ray diffraction data of the powder after annealing provide direct evidence that the iron oxide was formed during the sonochemical process.展开更多
文摘A molecular dynamics study to investigate the cavity control of Prefoldin based bio nano actuator is presented in this paper. Prefoldin is a molecular chaperone with a jellyfish-like structure containing six long coiled-coil tentacles and a large central cavity. We took the temperature and p H of the medium into account,and analyzed the conformational flexibility of the Prefoldin nano actuator in details. Results show that the prefoldin is a very flexible protein, the conformational state of which appears to depend on the temperature and p H values of the medium. In fact, combining these two control parameters, a suitable environment is provided to capture nano cargoes with specific dimensions. These properties of Prefoldin actuator can be used for drug delivery in the body.
文摘Cobalt ferrite nanoparticles（CFNPs） were prepared via a reverse micelle method. The CFNPs were subsequently coated with carbon shells by means of thermal chemical vapor deposition（TCVD）. In this process, acetylene gas（C2H2） was used as a carbon source and the coating was carried out for 1, 2, or 3 h at 750℃. The Ar/C2H2 ratio was 10：1. Heating during the TCVD process resulted in a NP core size that approached 30 nm; the thickness of the shell was less than 10 nm. The composition, structure, and morphology of the fabricated composites were characterized using X-ray diffraction, simultaneous thermal analysis, transmission electron microscopy, high-resolution transmission electron microscopy, and selected-area diffraction. A vibrating sample magnetometer was used to survey the samples＇ magnetic properties. The deposited carbon shell substantially affected the growth and magnetic properties of the CFNPs. Micro-Raman spectroscopy was used to study the carbon coating and revealed that the deposited carbon comprised graphite, multiwalled carbon nanotubes, and diamond-like carbon. With an increase in coating time, the intensity ratio between the amorphous and ordered peaks in the Raman spectra decreased, which indicated an increase in crystallite size.
文摘Preparation of iron oxide （α-Fe2O3） nanoparticles was carried out via a sonochemical process. The process parameters sucb as temperature, sonication time and power of ultrasonication play important roles in the size and morphology of the final products. The iron oxide nanoparticles were characterized by trans- mission electron microscopy, X-ray powder diffraction, and thermogravimetric and differential thermal analyses. From transmission electron microscopy observations, the size of the iron oxide nanoparticles is estimated to be significantly smaller than 19 nm. X-ray diffraction data of the powder after annealing provide direct evidence that the iron oxide was formed during the sonochemical process.
