BACKGROUND Aeromonas species are uncommon pathogens in biliary sepsis and cause substantial mortality in patients with impaired hepatobiliary function. Asia has the highest incidence of infection from Aeromonas,wherea...BACKGROUND Aeromonas species are uncommon pathogens in biliary sepsis and cause substantial mortality in patients with impaired hepatobiliary function. Asia has the highest incidence of infection from Aeromonas,whereas cases in the west are rare.CASE SUMMARY We report the case of a 64-year-old woman with advanced pancreatic cancer and jaundice who manifested fever,abdominal pain,severe thrombocytopenia,anemia and kidney failure following the insertion of a percutaneous transhepatic biliary drainage. Blood culture results revealed the presence of Aeromonas veronii biovar veronii(A. veronii biovar veronii). After antibiotic therapy and transfusions,the life-threatening clinical conditions of the patient improved and she was discharged.CONCLUSION This was a rare case of infection,probably the first to be reported in West countries,caused by A. veronii biovar veronii following biliary drainage. A finding of Aeromonas must alert clinician to the possibility of severe sepsis.展开更多
Mitochondria and neuronal activity:The brain is one of the highest energy demanding organs,consuming~20%of the total ATP produced by the whole body.Importantly,neurons mainly rely on ATP synthesized by mitochondrial b...Mitochondria and neuronal activity:The brain is one of the highest energy demanding organs,consuming~20%of the total ATP produced by the whole body.Importantly,neurons mainly rely on ATP synthesized by mitochondrial bioenergetics and neuronal activity is strictly dependent on specific mitochondrial localization at synapses,sites consuming a high amount of energy requested for both pre-and post-synaptic processes.Here,mitochondria produce ATP and buffer Ca^2+rises,two essential processes for neurotransmission and generation of membrane potential along the axon(Magistretti and Allaman,2015).展开更多
文摘BACKGROUND Aeromonas species are uncommon pathogens in biliary sepsis and cause substantial mortality in patients with impaired hepatobiliary function. Asia has the highest incidence of infection from Aeromonas,whereas cases in the west are rare.CASE SUMMARY We report the case of a 64-year-old woman with advanced pancreatic cancer and jaundice who manifested fever,abdominal pain,severe thrombocytopenia,anemia and kidney failure following the insertion of a percutaneous transhepatic biliary drainage. Blood culture results revealed the presence of Aeromonas veronii biovar veronii(A. veronii biovar veronii). After antibiotic therapy and transfusions,the life-threatening clinical conditions of the patient improved and she was discharged.CONCLUSION This was a rare case of infection,probably the first to be reported in West countries,caused by A. veronii biovar veronii following biliary drainage. A finding of Aeromonas must alert clinician to the possibility of severe sepsis.
基金This work was supported by the Italian Ministry of University and Scientific Research(PRIN 2017)the University of Padua(SID 2019)the UNIPD Funds for Research Equipment(2015).
文摘Mitochondria and neuronal activity:The brain is one of the highest energy demanding organs,consuming~20%of the total ATP produced by the whole body.Importantly,neurons mainly rely on ATP synthesized by mitochondrial bioenergetics and neuronal activity is strictly dependent on specific mitochondrial localization at synapses,sites consuming a high amount of energy requested for both pre-and post-synaptic processes.Here,mitochondria produce ATP and buffer Ca^2+rises,two essential processes for neurotransmission and generation of membrane potential along the axon(Magistretti and Allaman,2015).
