Objective:To evaluated the relationship between the genetic variations at IL-8 +2767 position with VL pathogenesis among Iranian patients.Methods:Three groups including patients with VL clinical presentation and leish...Objective:To evaluated the relationship between the genetic variations at IL-8 +2767 position with VL pathogenesis among Iranian patients.Methods:Three groups including patients with VL clinical presentation and leishmania seropositive(n=124).patients seropositive but without clinical presentation(n=82) and healthy controls(n=63) were selected to conduct this cross-sectional study.Polymorphism at +2767 position of IL-8 was investigated using PCR-RPLP techniques.Anti-leishmania antibody titration was evaluated by the immunoflorescence technique.Results:We observed higher significant frequencies +2767 A/A and A/T genotypes in groups I compared to group 2 and healthy controls(P=0.001).Also,patients in Group 1 carriyng A/A genotype showed higher liter of antileshmania antibody than patients with A/T and T/T genotypes(P=0.05).The validity of the data was analyzed using Hardy-Weinberg equilibrium and one way analysis of variance(ANOVA),as well as x^2tests.Conclusions:Our findings indicate that the IL-8 +2767 polymorphism is significantly involved in impaired immune responses against VL and it could be considered as a risk factor for the VL progress.展开更多
Despite advancements in computational resources,the discrete element method(DEM)still requires considerable computational time to solve detailed problems,especially when it comes to the large-scale models.In addition ...Despite advancements in computational resources,the discrete element method(DEM)still requires considerable computational time to solve detailed problems,especially when it comes to the large-scale models.In addition to the geometry scale of the problem,the particle shape has a dramatic effect on the computational cost of DEM.Therefore,many studies have been performed with simplified spherical particles or clumps.Particle scaling is an approach to increase the particle size to reduce the number of particles in the DEM.Although several particle scaling methods have been introduced,there are still some disagreements regarding their applicability to certain aspects of problems.In this study,the effect of particle scalping on the shear behavior of granular material is explored.Real granular particles were scanned and imported as polygonal particles in the direct shear test.The effect of particle size distri-bution,particle angularity,and the amount of scalping were investigated.The results show that particle scalping can simulate the correct shear behavior of the model with significant improvement in computational time.Also,the accuracy of the scalping method depends on the particle angularity and particle size range.展开更多
基金supported by a grant from the Tabriz University of Medical Sciences(No.91-20)
文摘Objective:To evaluated the relationship between the genetic variations at IL-8 +2767 position with VL pathogenesis among Iranian patients.Methods:Three groups including patients with VL clinical presentation and leishmania seropositive(n=124).patients seropositive but without clinical presentation(n=82) and healthy controls(n=63) were selected to conduct this cross-sectional study.Polymorphism at +2767 position of IL-8 was investigated using PCR-RPLP techniques.Anti-leishmania antibody titration was evaluated by the immunoflorescence technique.Results:We observed higher significant frequencies +2767 A/A and A/T genotypes in groups I compared to group 2 and healthy controls(P=0.001).Also,patients in Group 1 carriyng A/A genotype showed higher liter of antileshmania antibody than patients with A/T and T/T genotypes(P=0.05).The validity of the data was analyzed using Hardy-Weinberg equilibrium and one way analysis of variance(ANOVA),as well as x^2tests.Conclusions:Our findings indicate that the IL-8 +2767 polymorphism is significantly involved in impaired immune responses against VL and it could be considered as a risk factor for the VL progress.
文摘Despite advancements in computational resources,the discrete element method(DEM)still requires considerable computational time to solve detailed problems,especially when it comes to the large-scale models.In addition to the geometry scale of the problem,the particle shape has a dramatic effect on the computational cost of DEM.Therefore,many studies have been performed with simplified spherical particles or clumps.Particle scaling is an approach to increase the particle size to reduce the number of particles in the DEM.Although several particle scaling methods have been introduced,there are still some disagreements regarding their applicability to certain aspects of problems.In this study,the effect of particle scalping on the shear behavior of granular material is explored.Real granular particles were scanned and imported as polygonal particles in the direct shear test.The effect of particle size distri-bution,particle angularity,and the amount of scalping were investigated.The results show that particle scalping can simulate the correct shear behavior of the model with significant improvement in computational time.Also,the accuracy of the scalping method depends on the particle angularity and particle size range.
