Maternal urogenital human papillomavirus(HPV)infection may place neonates at risk of HPV acquisition and subsequently lower respiratory infections as HPV can influence development of immunity.The respiratory HPV preva...Maternal urogenital human papillomavirus(HPV)infection may place neonates at risk of HPV acquisition and subsequently lower respiratory infections as HPV can influence development of immunity.The respiratory HPV prevalence is not known in remote-dwelling Aboriginal infants,who are at high risk of respiratory infection and where the population prevalence of urogenital HPV in women is high.These data are necessary to inform HPV vaccination regimens.A retrospective analysis using PCR specific for HPV was performed on 64 stored nasopharyngeal swabs from remote-dwelling Aboriginal infants<6 months of age,with and without hospitalised pneumonia.HPV DNA was not detected in any specimen.Despite the negative result,we cannot exclude a role for HPV in respiratory infections affecting infants in this population;however,our data do not support HPV as an important contributor to acute respiratory infection in remote-dwelling Aboriginal children.展开更多
基金This work was supported by the Australian National Health and Medical Research Council(NHMRC,GNT1023781)HSV was supported by the NHMRC Centre for Research Excellence for Lung Health in Aboriginal and Torres Strait Islander children(GNT1079557)+2 种基金ABC is funded by a NHMRC Practitioner Fellowship(1154302)ACC was supported by a Career Development Fellowship(1068732)We wish to thank the families who participated in these studies.We thank Victor Oguoma for assistance with statistical analysis.
文摘Maternal urogenital human papillomavirus(HPV)infection may place neonates at risk of HPV acquisition and subsequently lower respiratory infections as HPV can influence development of immunity.The respiratory HPV prevalence is not known in remote-dwelling Aboriginal infants,who are at high risk of respiratory infection and where the population prevalence of urogenital HPV in women is high.These data are necessary to inform HPV vaccination regimens.A retrospective analysis using PCR specific for HPV was performed on 64 stored nasopharyngeal swabs from remote-dwelling Aboriginal infants<6 months of age,with and without hospitalised pneumonia.HPV DNA was not detected in any specimen.Despite the negative result,we cannot exclude a role for HPV in respiratory infections affecting infants in this population;however,our data do not support HPV as an important contributor to acute respiratory infection in remote-dwelling Aboriginal children.
