The paper is to study the structural changes in cortex and cerebellum of autopsies of subjects with schizophrenia. In the Pathology Department of the Psychiatric Hospital ＂Fray Bernardino ,Avarez＂, there are 410 aut...The paper is to study the structural changes in cortex and cerebellum of autopsies of subjects with schizophrenia. In the Pathology Department of the Psychiatric Hospital ＂Fray Bernardino ,Avarez＂, there are 410 autopsy cases with diagnosis of mental disease, from which 52 match schizophrenia. The aim of this work is to describe structural changes in the autopsy material and make markers in order to confirm neurodevelopment alterations. The tissues were preserved in formol, paraffin-embedded; cut into 5-7 μm slices; stained with H-E （Hematoxilin and Eosin）, Bielschowsky, crystal fast of violet. The observed changes were brain asymmetry, cortical dysplasia, neuronal distortion, axon bifurcation, neuronophagia and generalized demyelination. Schizophrenia is the result of several happenings, it is important to devise new treatment strategies for prevention and genetic counseling for population.展开更多
文摘The paper is to study the structural changes in cortex and cerebellum of autopsies of subjects with schizophrenia. In the Pathology Department of the Psychiatric Hospital ＂Fray Bernardino ,Avarez＂, there are 410 autopsy cases with diagnosis of mental disease, from which 52 match schizophrenia. The aim of this work is to describe structural changes in the autopsy material and make markers in order to confirm neurodevelopment alterations. The tissues were preserved in formol, paraffin-embedded; cut into 5-7 μm slices; stained with H-E （Hematoxilin and Eosin）, Bielschowsky, crystal fast of violet. The observed changes were brain asymmetry, cortical dysplasia, neuronal distortion, axon bifurcation, neuronophagia and generalized demyelination. Schizophrenia is the result of several happenings, it is important to devise new treatment strategies for prevention and genetic counseling for population.
