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FNDC4 and FNDC5 reduce SARS-CoV-2 entry points and spike glycoprotein S1-induced pyroptosis, apoptosis, and necroptosis in human adipocytes
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作者 Gema Frühbeck Victoria Catalán +7 位作者 Víctor Valentí Rafael Moncada Javier Gómez-Ambrosi Sara Becerril Camilo Silva Piero Portincasa Javier Escalada amaia rodríguez 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2021年第10期2457-2459,共3页
A sedentary lifestyle and obesity are important risk factors for severe COVID-19 complications and death[1,2].Excessive adipose tissue(AT)might contribute to more extensive viral spread with increased shedding,immune ... A sedentary lifestyle and obesity are important risk factors for severe COVID-19 complications and death[1,2].Excessive adipose tissue(AT)might contribute to more extensive viral spread with increased shedding,immune activation,and cytokine amplification[3].Several factors secreted by contracting muscle,termed myokines,mediate the beneficial effects of exercise in a wide range of diseases,including obesity[4].Thus,we conducted a study to explore the potential role of myokines of the fibronectin type III domain-containing family,FNDC4 and FNDC5,in mechanisms underlying the increased susceptibility to COVID-19 complications in obesity. 展开更多
关键词 FNDC5 OBESITY FND
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