Diabetes mellitus(DM)is a chromic metabolic disease that affects a large segment of the population worldwide.Physical inactivity,poor nutrition,and genetic predisposition are main risk factors for disease development....Diabetes mellitus(DM)is a chromic metabolic disease that affects a large segment of the population worldwide.Physical inactivity,poor nutrition,and genetic predisposition are main risk factors for disease development.In the last decade,it was clear to the scientific community that DM development is linked to a novel disease inducer that was later defined as diabetogenic factors of pollution and endocrine disrupting agents.Environmental pollution is exponentially increasing in uncontrolled manner in several countries.Environmental pollutants are of diverse nature and toxicities,including polyaromatic hydrocarbons(PAHs),pesticides,and heavy metals.In the current review,we shed light on the impact of each class of these pollutants and the underlined molecular mechanism of diabetes induction and biological toxicities.Finally,a brief overview about the connection between coronavirus disease 2019 and diabetes pandemics is presented.展开更多
文摘Diabetes mellitus(DM)is a chromic metabolic disease that affects a large segment of the population worldwide.Physical inactivity,poor nutrition,and genetic predisposition are main risk factors for disease development.In the last decade,it was clear to the scientific community that DM development is linked to a novel disease inducer that was later defined as diabetogenic factors of pollution and endocrine disrupting agents.Environmental pollution is exponentially increasing in uncontrolled manner in several countries.Environmental pollutants are of diverse nature and toxicities,including polyaromatic hydrocarbons(PAHs),pesticides,and heavy metals.In the current review,we shed light on the impact of each class of these pollutants and the underlined molecular mechanism of diabetes induction and biological toxicities.Finally,a brief overview about the connection between coronavirus disease 2019 and diabetes pandemics is presented.
