Universal access to medical procedures is deemed an advantage of the Canadian health care system. The purposes of this prospective study were to determine the degree to which the practice of colon cancer screening by ...Universal access to medical procedures is deemed an advantage of the Canadian health care system. The purposes of this prospective study were to determine the degree to which the practice of colon cancer screening by colonoscopy differed among socioeconomic classes and to assess adherence to screening guidelines. Consecutive patients scheduled to undergo colonoscopy at a single center between August 2000 and August 2002 completed a questionnaire that determined patient characteristics and indications for the procedure. The patients were divided into two groups: screening patients, defined as individuals who indicated they were undergoing colonoscopy for screening purposes and were asymptomatic, and a control group, which comprised patients undergoing colonoscopy because of symptoms. Statistical analysis was performed to determine if patients in the screening group had different characteristics with respect to socioeconomic class, compared with the control group. A total of 1088 patients completed the questionnaire: 707 (65%) had colonoscopy because of symptoms, compared with 381 (35%) who underwent a screening examination. Mean age and marital status were similar in both groups. Of all colonoscopy procedures, there was a significantly greater proportion of men undergoing colonoscopy for screening purposes: 199 (52.2%) vs. 294 (41.6%) in the symptomatic group (p = 0.001). Based on the Cochran-Armitage test, patients in the screening group had significantly higher education levels (p = 0.004) and household incomes (p = 0.001). Income and education level, two indices of socioeconomic status, are statistically significantly higher in patients undergoing screening colonoscopy compared with those having colonoscopy for any other reason.展开更多
Background: CD14 pathway is at the crossroads between infection and inf lammati on. In human pathology, divergent results have been reported on the relationship between a polymorphism in the promoter of receptor CD14 ...Background: CD14 pathway is at the crossroads between infection and inf lammati on. In human pathology, divergent results have been reported on the relationship between a polymorphism in the promoter of receptor CD14 (C260T), expression of soluble CD14(sCD14) receptor and atherosclerosis. The aim of the study was to in vestigate in a cross-sectional population-based sample the relationships betwe en C260T polymorphism in CD14 gene, sCD14 blood levels and arterial wall. Method s: Among 1015 subjects, randomly recruited by the Toulouse MONICA center between 1995 and 1997, 899 subjects with complete data for all the measurements, were a nalyzed. sCD14 was measured using an immunoenzymatic method. Common carotid inti ma-media thickness (IMT) and the presence of plaques in the carotid and femoral arteries were assessed by ultrasonography. A genotypic examination for the CD14 C260T polymorphism was performed. Results: An increase in sCD14 expression was observed in subjects carrying t allele (P < 0.01). No significant difference in intima-media thickness, number of plaques and pulse wave velocity was noticed a ccording to C260T polymorphism. An interaction (P < 0.05) was observed between C 260T polymorphism and current smoking in sCD14 expression: among smokers, no sig nificant change in sCD14 was observed in individuals carrying t allele. Conclusi on: Although (C260T) polymorphism in CD14 gene in this study is associated with expression of sCD14, no significant association was found between this polymorph ism and early markers of atherosclerosis. This polymorphism affects plasma level s of sCD14 in relation to current smoking status. Further studies are needed to determine whether this interaction influences the deleterious effect of smoking on vascular events.展开更多
文摘Universal access to medical procedures is deemed an advantage of the Canadian health care system. The purposes of this prospective study were to determine the degree to which the practice of colon cancer screening by colonoscopy differed among socioeconomic classes and to assess adherence to screening guidelines. Consecutive patients scheduled to undergo colonoscopy at a single center between August 2000 and August 2002 completed a questionnaire that determined patient characteristics and indications for the procedure. The patients were divided into two groups: screening patients, defined as individuals who indicated they were undergoing colonoscopy for screening purposes and were asymptomatic, and a control group, which comprised patients undergoing colonoscopy because of symptoms. Statistical analysis was performed to determine if patients in the screening group had different characteristics with respect to socioeconomic class, compared with the control group. A total of 1088 patients completed the questionnaire: 707 (65%) had colonoscopy because of symptoms, compared with 381 (35%) who underwent a screening examination. Mean age and marital status were similar in both groups. Of all colonoscopy procedures, there was a significantly greater proportion of men undergoing colonoscopy for screening purposes: 199 (52.2%) vs. 294 (41.6%) in the symptomatic group (p = 0.001). Based on the Cochran-Armitage test, patients in the screening group had significantly higher education levels (p = 0.004) and household incomes (p = 0.001). Income and education level, two indices of socioeconomic status, are statistically significantly higher in patients undergoing screening colonoscopy compared with those having colonoscopy for any other reason.
文摘Background: CD14 pathway is at the crossroads between infection and inf lammati on. In human pathology, divergent results have been reported on the relationship between a polymorphism in the promoter of receptor CD14 (C260T), expression of soluble CD14(sCD14) receptor and atherosclerosis. The aim of the study was to in vestigate in a cross-sectional population-based sample the relationships betwe en C260T polymorphism in CD14 gene, sCD14 blood levels and arterial wall. Method s: Among 1015 subjects, randomly recruited by the Toulouse MONICA center between 1995 and 1997, 899 subjects with complete data for all the measurements, were a nalyzed. sCD14 was measured using an immunoenzymatic method. Common carotid inti ma-media thickness (IMT) and the presence of plaques in the carotid and femoral arteries were assessed by ultrasonography. A genotypic examination for the CD14 C260T polymorphism was performed. Results: An increase in sCD14 expression was observed in subjects carrying t allele (P < 0.01). No significant difference in intima-media thickness, number of plaques and pulse wave velocity was noticed a ccording to C260T polymorphism. An interaction (P < 0.05) was observed between C 260T polymorphism and current smoking in sCD14 expression: among smokers, no sig nificant change in sCD14 was observed in individuals carrying t allele. Conclusi on: Although (C260T) polymorphism in CD14 gene in this study is associated with expression of sCD14, no significant association was found between this polymorph ism and early markers of atherosclerosis. This polymorphism affects plasma level s of sCD14 in relation to current smoking status. Further studies are needed to determine whether this interaction influences the deleterious effect of smoking on vascular events.
