This study aims to identify common contaminants in well water linked to an increase in colorectal cancer(CRC)incidence rates in North Dakota(ND)counties.County-specific incidence rates for CRC were obtained from the N...This study aims to identify common contaminants in well water linked to an increase in colorectal cancer(CRC)incidence rates in North Dakota(ND)counties.County-specific incidence rates for CRC were obtained from the ND Statewide Cancer Registry.Corresponding demographic,agricultural,and geophysical data were obtained from population-based sources.Associations between well water contaminants and CRC incidence were examined for 16 counties in ND with complete well water profiles between 1997-2019.Data were analyzed by multiple linear regression.Iron in well water exhibited a significant positive association with CRC incidence(4.75,P=0.001),and barium exhibited a small,but significant negative association(-0.06907,P=0.01).Residents in counties in ND with prevalent well water usage contaminated with iron may be at higher risk for CRC.展开更多
基金Supported by The National Institute of General Medical Sciences(NIGMS),No.1P20GM155890-01 to GGS.
文摘This study aims to identify common contaminants in well water linked to an increase in colorectal cancer(CRC)incidence rates in North Dakota(ND)counties.County-specific incidence rates for CRC were obtained from the ND Statewide Cancer Registry.Corresponding demographic,agricultural,and geophysical data were obtained from population-based sources.Associations between well water contaminants and CRC incidence were examined for 16 counties in ND with complete well water profiles between 1997-2019.Data were analyzed by multiple linear regression.Iron in well water exhibited a significant positive association with CRC incidence(4.75,P=0.001),and barium exhibited a small,but significant negative association(-0.06907,P=0.01).Residents in counties in ND with prevalent well water usage contaminated with iron may be at higher risk for CRC.
