A recent study published in Cell Metabolism by Codo et al.1 shows that metabolic rewiring of human monocytes by SARS-CoV-2 infection cultured under high glucose highly induces viral replication and cytokine production...A recent study published in Cell Metabolism by Codo et al.1 shows that metabolic rewiring of human monocytes by SARS-CoV-2 infection cultured under high glucose highly induces viral replication and cytokine production compromising T-cell response and function.Ultimately,this triggers lung epithelial cell death and,mechanistically,provides an explanation why people with diabetes might be more susceptible to develop severe COVID-19.展开更多
基金This work supported by the JDRF and German Research Foundation(DFG).
文摘A recent study published in Cell Metabolism by Codo et al.1 shows that metabolic rewiring of human monocytes by SARS-CoV-2 infection cultured under high glucose highly induces viral replication and cytokine production compromising T-cell response and function.Ultimately,this triggers lung epithelial cell death and,mechanistically,provides an explanation why people with diabetes might be more susceptible to develop severe COVID-19.
