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In <i>Vitro</i>Anthelmintic Activity of Leaf Extracts of <i>Celosia</i>laxa Schum. &Thonn
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作者 Sylvester Nefai Mathias Emmanuel Halilu Mshelia +1 位作者 Bala Bilyaminu Danbala aminu ahmed biambo 《Open Journal of Applied Sciences》 2021年第12期1277-1286,共10页
<strong>Background:</strong><span style="font-family:;" "=""> <i>Celosia laxa (</i>Amaranthaceae) is mainly a west African plant species used in Traditional Medic... <strong>Background:</strong><span style="font-family:;" "=""> <i>Celosia laxa (</i>Amaranthaceae) is mainly a west African plant species used in Traditional Medicine as an anthelmintic, anticancer, antibacterial and analgesic agent. The seeming prevalence of worm infection in Gwandu </span><span style="font-family:;" "="">community of Gwandu Local Government Area of Kebbi State-Nigeria</span><span style="font-family:;" "=""> prompted this study. <b>Methods:</b><i> </i>Whole plant of <i>C. laxa</i> extracts obtained through maceration in aqueous (AE), methanol (ME) and hexane (HE) solvents were investi</span><span style="font-family:;" "="">gated for their anthelmintic activity against Indian earthworms (<i>Pheretima posthuman) </i>at four different (gradient) concentrations of<i> </i>10, 20, 40 and 8<span>0 (mg/ml) for each extract. The study involved the determination of time of paralysis (P) and time of death (D) of the worms. <b>Results:</b> Both the aqueous and ethanolic extracts exhibited significant anthelmintic activity at the highest con</span>centration of 80 mg/ml as compared to the standard drug, praziquantel (10</span><span style="font-family:;" "=""> </span><span style="font-family:;" "="">mg/ml). Consequently, the aqueous extract showed a higher activity at 80</span><span style="font-family:;" "=""> </span><span style="font-family:;" "="">mg/ml compared to standard praziquantel at 10</span><span style="font-family:;" "=""> </span><span style="font-family:;" "="">mg/ml (with no significant value of p</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><</span><span style="font-family:;" "=""> </span><span style="font-family:;" "="">0.05). The time of paralysis and death observed for AE was 13.0 ± 1.8 and 16.8 ± 1.5 while the ME was less bioactive with 15.7 ± 0.5 and 23.0 ± 0.0 respectively. However, on the other hand, the hexane extract recorded no-activity on all the test</span><span style="font-family:;" "=""> </span><span style="font-family:;" "="">sample concentrations, compared</span><span style="font-family:;" "=""> to </span><span style="font-family:;" "="">the standard drug (with a significant difference of p-value, p</span><span style="font-family:;" "=""> </span><span style="font-family:;" "="">></span><span style="font-family:;" "=""> </span><span style="font-family:;" "="">0.05). <b>Conclusion:</b> It was concluded that the leaves of <i>C. laxa</i> </span><span style="font-family:;" "="">are</span><span style="font-family:;" "=""> likely to yield a potent anthelminthic drug owing to soluble phytoconstituent which are largely hydrophilicity extracted by the polar solvents. Also, considering that the plants’ mode of preparation for use by the locals was aqueous decoction before administration, the folkloric therapeutic claims can be said to have been justified.</span> 展开更多
关键词 ANTHELMINTIC Extracts MACERATION PRAZIQUANTEL PHYTOCONSTITUENTS Indian Earthworm
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